Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J cells, a clonal population of the human erythroid K-562 leukemia cells. Maturing HL-205 cells acquired either granulocytic or monocytic markers, namely, reactivity with the mu...

Cytogenetic analysis of solid tumors with comparative genomic hybridization (CGH) is hampered by the dilution of DNA from individual tumor subpopulations with DNA from other cells. We investigated to what extent this dilution effect can be alleviated using fluorescence activated cell sorting (flow sorting) of experimental DNA heteroploid cell mixtures prior to CGH. From mixtures of normal lymph...

Stroke is a major clinical problem, and acute pharmacological intervention with neuroprotective agents has so far been unsuccessful. Recently, there has been considerable interest in the potential therapeutic benefit of nitrone-derived free radical trapping agents as neuroprotective agents. Nitrone compounds have been shown to be beneficial in animal models of various diseases, and the prototyp...

Skin Reactions to Practolol P. Wright, F.R.C.S ........................560 Vitamin A, Pregnancy, and Oral Contraceptives Isabel Gal, M.D ......................... 560 Complication of Proximal Gastric Vagotomy J. H. Wyllie, F.R.C.S ..................... 561 Drugs for Gastric Ulceration Surgeon-Captain T. L. Cleave, M.R.C.P.....561 Pregnancy Associated with Copper-containing I.U.D. V. Sivanesarat...

Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinasfs. suppressed growth and induced differentiation in HL-205 cells, a clonal population of the human promyelocytic HL-60 leukemia cells, and in K-562-J cells, a clonal population of the human erythroid K-562 leukemia cells. Maturing I IL-205 cells acquired either granulocytic or monocytic markers, namely, reactivity with the ...