INTRODUCTION Streptococcus pneumoniae is a worldwide leading cause of morbidity and mortality, while susceptibility towards penicillin and macrolides can be less than 50% in many regions. METHODOLOGY A total of 150 isolates of S. pneumoniae causative of invasive diseases in children were characterized, of which 24.6% had a fatal outcome. RESULTS The most prevalent serotypes were 19F, 6B, 23...

In the present study, the possible role of free radicals in aminophylline-induced seizures was evaluated in albino rats. Aminophylline (theophylline in ethylene diamine; 50 - 300 mg/kg) induced convulsions in rats in a dose-dependent manner, and both incidence of seizure and mortality were maximum at 300 mg/kg. Conventional anti-epileptics, diphenylhydantoin and dizocilpine, as well as adenosin...

Objective: To investigate the antifungal, haemolytic and cytotoxic activity of methanol and methanol: chloroform extracts of the marine Mollusks (10 Gastropods, 5 Bivalves, 2 Cephalopods) and 1 Echinoderm. Methods: Crude methanol and methanol: chloroform extracts of the marine Mollusks (10 Gastropods, 5 Bivalves, 2 Cephalopods) and 1 Echinoderm were tested for antifungal activity using disc dif...

in the present work, the bioassay screening of the essential oil and various extracts of two plants including fruits of heracleum persicum desf. and rhizomes of zingiber officinale rosc. have been studied with brine shrimp test. there is only one report about cytotoxicity of h. sphondylium in literature and so h. persicum has been used as second selection. at first essentials oil and various ex...

Numerous studies have been focused on natural anticarcinogenic agents. Many antioxidants have been identified as anticarcinogens. Antimutagens have also been proposed as cancer chemopreventive agents. The use of natural products as anticancer has a long history that began with traditional medicine. The aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

Numerous studies have been focused on natural anticarcinogenic agents. Many antioxidants have been identified as anticarcinogens. Antimutagens have also been proposed as cancer chemopreventive agents. The use of natural products as anticancer has a long history that began with traditional medicine. The aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

The lethality of a gene is a fundamental and representative measure for understanding the function of a gene and its associated bio-systems. Recently, many research groups have started focusing on the concept of synthetic lethality. The synthetic lethality between genes is defined by the combination of mutations in two genes causing cell death. Here, we confirm that synthetic lethality and cell...

Results with four pathogenic avian Escherichia coli isolates and one avirulent isolate in a complement resistance test, a chicken lethality test, and a chicken embryo lethality test were compared. Results of the complement resistance test with these isolates were highly correlated to results of the chicken lethality test of virulence. The chicken embryo test yielded results that were of a mediu...

Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with an LC(50) of 1031 microg/ml. The two main compounds present in the most active ...