نتایج جستجو برای: 5 trisubstituted imidazoles

تعداد نتایج: 1219018  

2011
Saman Damavandi

A survey of the pertinent literature reveals that aryl imidazoles have been found to possess a wide spectrum of biological activity such as antibacterial [1], antirheumatoid arthritis [2], antitubercular [3], antiviral [4], anti-inflammatory [5] and anticancer activities [6-8]. Specifically, it has been revealed from the literature that imidazoles fused with indole nucleus possess various biolo...

Journal: :International Journal of Current Science Research and Review 2022

The imidazole moiety finds itself in a host of compounds having profound biological and medicinal properties. This has led to the quest develop cost effective, desirably greener synthetic route access this azole. In review, ultrasonic irradiation assisted syntheses trisubstitued derivatives have been discussed which make use different environment friendly efficient catalytic systems. They found...

Journal: :Molecules 2018
Francesco Ansideri Stanislav Andreev Annette Kuhn Wolfgang Albrecht Stefan A Laufer Pierre Koch

An alternative strategy for the synthesis of 1-aryl- and 1-alkyl-2-methylsulfanyl-4-(4-fluorophenyl)-5-(pyridin-4-yl)imidazoles as potential p38α mitogen-activated protein kinase inhibitors is reported. The regioselective N-substitution of the imidazole ring was achieved by treatment of α-aminoketones with different aryl or alkyl isothiocyanates. In contrast to previously published synthesis ro...

Journal: :Bulletin of the Chemical Society of Japan 1960

Journal: :Chemical science 2017
Nicholas J Race Adele Faulkner Gabriele Fumagalli Takayuki Yamauchi James S Scott Marie Rydén-Landergren Hazel A Sparkes John F Bower

The first examples of highly enantioselective Narasaka-Heck cyclizations are described. A SPINOL-derived P,N-ligand system enables Pd-catalyzed 5-exo cyclization of a range of oxime esters with sterically diverse trisubstituted alkenes to generate dihydropyrroles containing tetrasubstituted nitrogen-bearing stereocenters in 56 to 86% yield and 90 : 10 to 95 : 5 e.r. These processes are rare exa...

Journal: :Antimicrobial agents and chemotherapy 2005
Ryan A Helmick Arin E Fletcher Anne M Gardner Christopher R Gessner Angela N Hvitved Michael C Gustin Paul R Gardner

Flavohemoglobins metabolize nitric oxide (NO) to nitrate and protect bacteria and fungi from NO-mediated damage, growth inhibition, and killing by NO-releasing immune cells. Antimicrobial imidazoles were tested for their ability to coordinate flavohemoglobin and inhibit its NO dioxygenase (NOD) function. Miconazole, econazole, clotrimazole, and ketoconazole inhibited the NOD activity of Escheri...

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