5-Fluorouracil (5-FU) is an anticancer drug. In this work, we have investigated the electronic properties and topological analysis of interaction between 5-FU and carbon nanocone and BN nanocone. The structural stability of isomer complexes of 5-FU with carbon nanocone and BN nanocone have been investigated for two position of interactions. We have found that the most stable complexes are forme...

Abstract Introduction Despite the known cytotoxic and hepatotoxic effects of most common chemotherapy drugs, their use in context liver regeneration as part antitumor treatment is controversial. Methods Thirty-six WAG/RijHsd rats were induced to selective portal ligation 50% hepatic parenchyma, divided into 3 experimental groups. 72 hours before, two groups treated with 5-Fluorouracil (50mg/kg)...

Objective: The study's objective involved compatibility studies to investigate the possible interactions between 5-fluorouracil (5-FU) and four different lipids, most appropriate lipid was chosen. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier Transform Infrared spectroscopy (FT-IR) are used for study 5-FU several excipients as cholesterol, compritol®, stearic acid, g...

understanding the mechanism of tumor resistance is critical for cancer therapy. in this study, we investigated the effect of carcinoembryonic antigen (cea) overexpression on uv-and 5-fluorouracil (5-fu)-induced apoptosis and autophagy in colorectal cancer cells. we used histone deacetylase (hdac) inhibitor, nab and dna demethylating agent, 5- azacytidine (5-aza) to induce cea expression in ht29...

BACKGROUND 5-Fluorouracil (5-FU) is the backbone of chemotherapy regimens approved for treatment of colorectal cancer. The incidence of cardiotoxicity associated with 5-FU ranges from 1.5% to 18%; 48% as anginal symptoms and 2% as cardiogenic shock. Cardiotoxicity is unpredictable and no alternative chemotherapeutics have been defined so far. PATIENTS AND METHODS We present a case series of s...

two common single nucleotide polymorphisms (snps) of the human tlr4 gene, namely asp299gly (d299g) and thr399ile (t399i), have been shown to impair the ability of certain individuals to respond properly to tlr4 ligands. 5-fluorouracil (5-fu) is widely used for the treatment of patients with advanced colon cancers. the present study examined the impact of two common polymorphisms of the tlr4 gen...

Dihydropyrimidine dehydrogenase (DPD) is the initial rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU), accounting for catabolism of over 85% of an administered dose of 5-FU. DPD plays an important role in regulating the availability of 5-FU for anabolism. DPD also accounts for much of the variability observed with the therapeutic use of 5-FU. This includes variable 5-FU levels ov...

Multifocal inflammatory leukoencephalopathy (MIL) is a cerebral demyelinating syndrome that develops after chemotherapy with 5-fluorouracil (5-FU) and levamisole. The authors report a patient who developed MIL after 5-FU administration not in association with levamisole. She was subsequently diagnosed with partial deficiency of dihydropyrimidine dehydrogenase, an enzyme necessary for 5-FU catab...

Hepatotoxic effect of 5-Fluourouracil (5-FU) can deprive cancer patients of maximum therapeutic benefits. Aim: This study assessed the ability of selenium (Se) to protect against hepatotoxicity induced by 5-FU in rats. Forty adult albino rats were groups and used. Rats in group A (control) were treated intraperitoneally (ip) with 0.2ml of normal saline daily for 5 days. Rats in groups B1-B3 wer...