The conditional expression of hairpin constructs in Drosophila melanogaster has emerged in recent years as a method of choice in functional genomic studies. To date, upstream activating site– driven RNA interference constructs have been inserted into the genome randomly using P-element–mediated transformation, which can result in false negatives due to variable expression. To avoid this problem...

Background: The association between diet quality and risk of incident cardiovascular disease (CVD) or heart failure (HF) in postmenopausal women is uncertain. Objective: This study aimed to determine whether a conventional index [Alternate Healthy Eating Index (AHEI)] or a novel index [Women’s Health Initiative (WHI) Dietary Modification Index (DMI)] of diet quality was associated with the risk...

In this paper, relying on previous results of one of us on harmonic analysis, we derive the complete spectrum of Osp(3|4) × SU(3) multiplets that one obtains compactifying D=11 supergravity on the unique homogeneous space N that has a tri-sasakian structure, namely leads to N = 3 supersymmetry both in the four– dimensional bulk and on the three–dimensional boundary. As in previously analyzed ca...

Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival of motor neuron 1, telomeric (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a ubiquitously expressed protein, leads to spinal motor neuron-specific degeneration in individuals affected by SMA remains unknown. In this stu...