Rats chronically cannulated in the carotid artery and the muscular branch of the femoral vein were subjected to a cold (4 degrees C) environment for up to 2 h. The changes in blood flow (measured with 46Sc microspheres) and arterio-venous differences in the concentrations of glucose, lactate, triacylglycerols and amino acids allowed the estimation of substrate (and energy) balances across the h...

Bone metastasis occurs as a result of a complex pathophysiologic process between host and tumor cells leading to cellular invasion, migration adhesion, and stimulation of osteoclastic and osteoblastic activity. The process is mediated by parathyroid hormones, cytokines, and tumor-derived factors. Several sequelae occur as a result of osseous metastases and resulting bone pain can lead to signif...

Infrared attenuated total reflection spectroscopy has been used to study the interaction of DMMP vapor with SiO(2), Al(2)O(3), and AlO(OH) vs relative humidity (RH) and DMMP partial pressure (P/P(0)). For SiO(2) the growth with increasing RH of ice-like and liquid-like layers is seen in agreement with previous work. H↔D exchange during exposure to H(2)O and D(2)O indicates that the ice-like lay...

The purpose of this study was to assess a 3-dimensional (3D)– only PET scanner (ECAT EXACT3D) for its use in the absolute quantification of myocardial blood flow (MBF) using H2O. Methods: Nine large white pigs were scanned with H2O and C15O before and after partially occluding the circumflex (n 4) or the left anterior descending (n 5) coronary artery at rest and during hyperemia induced by intr...

BACKGROUND A previous study from our laboratory showed that polybrominated diphenyl ethers (PBDEs) were metabolized to hydroxylated PBDEs (HO-PBDEs) in mice and that para-HO-PBDEs were the most abundant and, potentially, the most toxic metabolites. OBJECTIVE The goal of this study was to determine the concentrations of HO-PBDEs in blood from pregnant women, who had not been intentionally or o...

An extension of the planar Smale-Birkhoff homoclinic theorem to the case of a heteroclinic saddle connection containing a finite number of fixed points is presented. This extension is used to find chaotic dynamics present in certain time-periodic perturbations of planar fluid models. Specifically, the Kelvin-Stuart cat's eye flow is studied, a model for a vortex pattern found in shear layers. A...

Purpose: The objective of this study was to determine the fate of the Ho-chitosan complex (DW-166HC) in rats by examining its absorption, distribution and excretion after administration into the prostate. Methods: About 100 Ci of DW-166HC [containing 0.1875 mg of Ho(NO3)3·5H2O and 0.25 mg of chitosan] was administered intraprostatically. The level of radioactivity in blood, urinary and faecal e...

Recent in vivo and in vitro experiments indicated that methoxylated polybrominated diphenyl ethers (MeO-PBDEs) can be biotransformed into hydroxylated PBDEs (HO-PBDEs) that are more toxic than PBDEs and MeO-PBDEs. Nevertheless, the enzymatic transformation mechanism is not clear. We hypothesized that cytochrome P450 enzymes (CYPs) play a key role in the transformation and employed the density f...

Stillbirth (SB) often results in reduced milk yield, compromised reproductive performance, and decreased dam longevity. Corrective mating can be used as a short-term solution to the problem, but long-term improvement of the population requires the routine calculation of genetic evaluations. Breeding values for SB have been available for Holstein (HO) bulls since 2006, but not for Brown Swiss (B...

A time-reversal-violating spin-correlation coefficient in the total cross section for polarized neutrons incident on a tensor rank-2 polarized target is calculated by assuming a time-reversal-noninvariant, parity-conserving “five-fold” interaction in the neutron-nucleus optical potential. Results are presented for the system n + Ho for neutron incident energies covering the range 1–20 MeV. From...