نتایج جستجو برای: 4 thiazolidinone

تعداد نتایج: 1303703  

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2009
Wael A El-Sayed Yasser K Abdel-Monem Nabil M Yousif Nashwa Tawfek Mohamed T Shaaban Adel A-H Abdel-Rahman

A number of new disubstituted 2,5-thiazolidinone derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). They displayed different degrees of antimicrobial activities or inhibitory actions.

2011
Mostafa M. Ghorab Fatma A. Ragab Helmy I. Heiba Hebaallah M. Agha

Several novel N substituted sulfapyridine derivatives were synthesized by condensation of 2-ChloroN-(4-(N-pyridin-2-ylsulfamoyl)phenyl) acetamide 2 with different amino acids, amines, malononitrile, or ammonium thiocyanate to yield the corresponding alkanoic acid derivatives 3a-f, acetamide derivatives 48, pyrrole derivatives 912, and thiazolidinone derivative 13. The newly synthesized compound...

Journal: :Acta poloniae pharmaceutica 2016
Aakash Deep Pradeep Kumar Balasubramanian Narasimhan Siong Meng Lim Kalavathy Ramasamy Rakesh Kumar Mishra Vasudevan Mani

In this study, a novel series of 4-thiazolidinone derivatives (1-17) was synthesized and evaluated for its in vitro antimicrobial and anticancer potentials. N-(2-(5-(4-nitrobenzylidene)-2-(4-chlorophenyl)-4-oxothia- zolidin-3-ylamino)-2-oxoethyl) benzamide (7, pMICam = 1.86 µM/mL) was found to be the most active antimi- crobial agent. The anticancer study results demonstrated that N-(2-(5-(4-hy...

Journal: :The Journal of clinical investigation 2002
Tonghui Ma Jay R Thiagarajah Hong Yang Nitin D Sonawane Chiara Folli Luis J V Galietta A S Verkman

Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when defective, causes the lethal genetic disease cystic fibrosis. We screened 50,000 chemically diverse compounds for inhibition of cAMP/...

Journal: :Chemical & pharmaceutical bulletin 2000
F Abe T Yamauchi

Steroidal compounds in the roots of Asclepias tuberosa were investigated and 17alpha-hydroxyandrosta-4,6,15-trien-3-one 17-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside, termed ascandroside, was isolated from the CHCl3-soluble fraction. Among five doubly-linked cardenolide glycosides, two were identified as 3'-spiro-linked thiazolidinone (4) and S-oxythiazolidinone derivatives (5) o...

Journal: :Biochemistry research international 2016
Amit Gupta Rajendra Singh Pankaj K Sonar Shailendra K Saraf

A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 µg/mL, respectively. Minimum inhibitory concentrations of all the compounds were also det...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2012
Divyesh Patel Rahul Patel Premlata Kumari Navin B Patel

A novel series of thiazolidinone derivatives, namely 4-{4-dimethylamino-6-[4-oxo-2-phenyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-thiazolidin-3-yl]-[1,3,5]-triazin-2-yloxy}-1-methyl-1H-quinolin-2-ones, have been synthesized from the key intermediate 4-(4-amino-6-dimethylamino-[1,3,5]-triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (5). Compound 5 was condensed with various aldehydes to give Schiff ...

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