Objective Metformin is the recommended initial drug treatment in type 2 diabetes mellitus, but there is no clearly preferred choice for an additional drug when indicated. We compare the counterfactual drug effectiveness in lowering glycated hemoglobin (HbA1c) levels and effect on body mass index (BMI) of four diabetes second-line drug classes using electronic health records. Study design and ...

In the present work, we represent two thiazolidinediones, namely (Z)-5-(4-methoxybenzylidene) thiazolidine-2,4-dione (MeOTZD) and (Z)-5-(4-methylbenzylidene) (MeTZD), as corrosion inhibitors for carbon steel (CS) in 1.0 M HCl solution. Techniques gravimetric methods, electrochemical measurements, morphological characterization were used to conduct experimental evaluations. Additionally, calcula...

Submit Manuscript | http://medcraveonline.com Abbreviations: PCMH: Patient Centered Medical Home; SGLT-2 Inhibitors: Sodium Glucose Cotransport-2 Inhibitors; T2DM: Type 2 Diabetes; A1c: Hemoglobin A1c; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; Egfr: Estimated Glomerular Filtration Rate; CDC: Centers For Disease Control; ADA: American Diabetes Association; AACE: American Acade...

Table 1. Relative effect sizes for change of HbA1c, risk of nausea and treatment discontinuation due to AEs, all GLP-1 RA treatments compared to placebo. • In addition to GLP-1 RAs, two sulfonylureas (glibenclamide, glimepiride), two thiazolidinediones (rosiglitazone, pioglitazone) the dipeptidyl peptidase-4 inhibitor sitagliptin and insulin were included to ensure a connected network of compar...

The topic of increased risk of bone fracture associated with thiazolidinediones (TZD) treatment first drew international attention when a higher rate of fractures in women with diabetes treated with rosiglitazone was reported in the A Diabetes Outcome Program Trial (ADOPT). Subsequently, a number of clinical trials and observational studies addressing this issue have been reported and most of t...

A large number of cardiology clinical trials have mortality as an endpoint unless adequate surrogate endpoints are available. Although there are nine classes of agents used in the treatment of diabetes mellitus, none have shown a mortality benefit in clinical trials. The United Kingdom Prospective Diabetic Study was the first to suggest that metformin given for diabetes mellitus had a trend tow...

Even before its advent in 1999; Pioglitazone as well as other members of the thiazolidinediones group have been questioned for a relationship with colon carcinoma in mice; an adverse effect that was subsequently evidenced to occur also in some types of human colon cancer cells [2,3]. Similarly, preclinical studies have also showed that bladder tumors were observed in male rats receiving doses o...

Herein we outline the antibacterial activity of amino acid containing thiazolidinediones and rhodanines against Gram-positive bacteria Staphylococcus aureus ATCC 31890, Staphylococcus epidermidis and Bacillus subtilis ATCC 6633. The rhodanine derivatives were generally more active than the analogous thiazolidinediones. Compounds of series 5 showed some selectivity for Bacillus subtilis ATCC 663...

INTRODUCTION The peroxisome proliferator-activated receptor-γ agonists rosiglitazone and pioglitazone activate glucocorticoid receptors and have an immunomodulatory effect. The authors aimed to systematically determine the risk of pneumonia or lower respiratory tract infections associated with thiazolidinediones. METHODS Systematic searches of MEDLINE, EMBASE, regulatory documents and trial r...