http://bmj.com/cgi/content/full/321/7258/393 Updated information and services can be found at: These include: References http://bmj.com/cgi/content/full/321/7258/393#otherarticles 1 online articles that cite this article can be accessed at: Rapid responses http://bmj.com/cgi/eletter-submit/321/7258/393 You can respond to this article at: http://bmj.com/cgi/content/full/321/7258/393#responses at...

Hyperglycemia is one of the possible causes for osteoporosis and bone fracture in diabetes mellitus. Here we modeled diabetes-induced osteoporosis in vitro using preosteoblastic cell line MC3T3-E1 and a diabetic mice model for in vivo studies. We found that in addition to reducing osteoblast viability and differentiation (mineralization), culture in elevated glucose down regulated microRNA-378 ...

Both classical brown adipocytes and brown-like beige adipocytes are considered as promising therapeutic targets for obesity; however, their development, relative importance and functional coordination are not well understood. Here we show that a modest expression of miR-378/378* in adipose tissue specifically increases classical brown fat (BAT) mass, but not white fat (WAT) mass. Remarkably, BA...

MicroRNA-378 (miR-378) is dysregulated in multiple malignancies and is associated with tumor progression. However, the expression and mechanism of miR-378 in pituitary adenoma (PA) remains to be elucidated. In the present study, the role and mechanism of miR-378 in PA tumorigenesis and development was investigated. It was revealed that the levels of miR-378 expression were markedly downregulate...

349. Surveillance of Carbapenem Resistance and the First Case of NDM-7producing Klebsiella pneumoniae in the Philippines Andrew Chou, MD; Michael Evangelista; Arielle Kae Sulit; Brian Torres; Marylette Roa; David C. Klinzing, PhD; Lynn Zechiedrich, PhD; Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX; Verna and Marrs Mclean Department of Biochemis...

AIMS Excessively high left ventricle mass is an independent predictor of adverse prognosis. MicroRNAs (miRs) play crucial roles in the regulation of left ventricle hypertrophy (LVH). However, few circulating miRs have been established as predictors of LVH in aortic stenosis (AS) patients. In this study, we aimed to investigate whether circulating levels of miR-1, miR-133, and miR-378 predict LV...

EGFR-inhibitor (Cetuximab) is one of the main targeted drugs used for metastatic colorectal carcinoma (CRC). The benefit from Cetuximab appears to be limited to a subtype of patients, not for the patients with tumors harboring mutated BRAF or KRAS genes; unfortunately, it accounts for ~40-50% of CRC cases. Previous studies have connected higher expression levels of miR-378 to be commonly presen...

The distinction can be conceptual, like in multi-player games: players can be physically and geographically distributed but connected to a server and seeing the shared state of the game, or physically together but communicate following certain rule and not seeing each other's state. Indeed a system can have both aspects at the same time, with some data shared, and some data private. In general,...