STUDY OBJECTIVE To assess the frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in patients with allergic bronchopulmonary aspergillosis (ABPA). DESIGN Case-control study. All subjects in the study were screened for the presence of 13 mutations in the CFTR gene (R117H, 621 + 1G(-)>T, R334 W, Delta F508, Delta I507, 1717-1G(-)>A, G542X, R553X, G551D, R1162X...

Books [1] "New Trends in Fuzzy Logic", Bonarini A., Mancini A., Masulli F., Petrosino A. Ed.s, (1996), World Scientific Publishing, Singapore. [2] "New Trends in Fuzzy Logic II", Castellano M., Blonda P., Petrosino A. Ed.s, (1998), World Scientific Publishing, Singapore. [3] "Visual Atention Mechanisms", Cantoni V., Marinaro M., Petrosino A., Ed.s, (2002), Kluwer/Plenum Press, New York. [4] "Fu...

PURPOSE Neuroblastoma is the most common extracranial solid cancer type in childhood, and high-risk patients have poor prognosis despite aggressive multimodal treatment. Neuroblastoma-driven inflammation contributes to the induction of suppressive myeloid cells that hamper efficient antitumor immune responses. Therefore, we sought to enhance antitumor immunity by removing immunosuppression medi...

Objectives: Bile acids promoted the replication of hepatitis C virus (HCV) and compromised the anti-HCV effects of interferon (IFN) in replicon-harboring cells. To explore a potential mechanism for the observation, we studied the effects of bile acids on the epidermal growth factor receptor (EGFR) and the extracellular signal-regulated kinase (ERK) pathway in association with HCV replication i...

Objectives: Bile acids promoted the replication of hepatitis C virus (HCV) and compromised the anti-HCV effects of interferon (IFN) in replicon-harboring cells. To explore a potential mechanism for the observation, we studied the effects of bile acids on the epidermal growth factor receptor (EGFR) and the extracellular signal-regulated kinase (ERK) pathway in association with HCV replication i...

Abstract Aims Late-life depression has substantial impacts on individuals, families and society. Knowledge gaps remain in estimating the economic associated with late-life by symptom severity, which implications for resource prioritisation research design (such as modelling). This study examined incremental health social care expenditure of depressive symptoms severity. Methods We analysed data...

OBJECTIVES The pharmacokinetic (PK) parameters of artesunate, recently discovered to possess promising trematocidal activity, and its main metabolite dihydroartemisinin (DHA) were determined in rats infected with hepatic and biliary stages of Fasciola hepatica and compared with uninfected rats after single intragastric and intravenous (iv) doses. METHODS Rats infected with F. hepatica for 25 ...

STUDY OBJECTIVES Cystic fibrosis (CF) is one of the most common inherited diseases among whites. Since the cloning of the CF transmembrane conductance regulator (CFTR) gene, a number of studies have focused on associations between the genotype and phenotype in CF. This had led to the progressive identification of new groups of patients, including those who have mild lung disease and those who h...

BACKGROUND Mandatory newborn screening for metabolic disorders has not been implemented in most parts of China. Newborn mortality and morbidity could be markedly reduced by early diagnosis and treatment of inborn errors of metabolism (IEM). Methods of screening for IEM by tandem mass spectrometry (MS/MS) have been developed, and their advantages include rapid testing, high sensitivity, high spe...