Variant-specific zinc transporter 8 autoantibodies (ZnT8A) against either arginine (R) or tryptophan (W) at amino acid (aa) position 325 of the zinc transporter 8 (ZnT8) has been identified in type 1 diabetes (T1D) patients. Reciprocal cross-over tests revealed differences in half-maximal binding to indicate variable affinity of patient ZnT8 autoantibodies. Insufficient recombinant ZnT8 variant...

BACKGROUND The prevalence of excess weight, including overweight and obesity, is increasing with a high cost on health in society. METHODS Consecutive cases with excess weight, aged between 50 and 70 years and desiring weight loss, were divided into two subgroups according to wishes of patients about whether they prefer medication or just a diet. Metformin at a daily dose of 2,550 mg was give...

TTK m. 369 hükmü “yönetim kurulu üyeleri” ve “yönetimle görevli üçüncü kişilerin” özen bağlılık yükümlülüğünü düzenlemektedir. İlgili hükme göre bu kişiler görevlerini tedbirli bir yöneticinin özeniyle yerine getirmek şirketin menfaatlerini dürüstlük kurallarına uyarak gözetme yükümlülüğü altındadırlar. TTK’nın temsil yönetime ilişkin hükümleri incelendiğinde ifade olunan “yükümlü kılınanlar çe...

Axel Kuhn (Hrsg.): Volksunruhen in Württemberg 1789-1801 (Aufklärung und Revolution. Beiträge zur Geschichte des bürgerlichen Zeitalters. Band 2) - Stuttgart: Frommann-Holzboog, 1991. 369 S.

OBJECTIVE Diabetic nephropathy clusters in families, suggesting that genetic factors play a role in its pathogenesis. We investigated whether similar clustering exists for proliferative retinopathy in families with two or more siblings with type 1 diabetes. RESEARCH DESIGN AND METHODS The FinnDiane Study has characterized 20% (4,800 patients) of adults with type 1 diabetes in Finland. In 188 ...

may make it a more appropriate agent for testing the vasodilator response. Background – In patients with primary (Thorax 1997;52:369–372) pulmonary hypertension who respond to vasodilators acutely, survival can be im