Background Takayasu arteritis (TAK) is one form of the large vessel vasculitis and predominantly affects young female. TAK sometimes coexists with other inflammatory diseases which include ulcerative colitis (UC) spondyloarthropathy. Recent evidences revealed close genetic background between these diseases, we found common autoantibodies against endothelial protein C receptor among UC. These su...

Wilson et al. raisea number of issues that, according to their opinion, require explanation. They support their comment on their estimation of the accessibility of β-cyclodextrin (β-CD) sites of four polymers prepared by cross-linking β-CD with divinylsulfone (DVS) at four stoichiometries. In particular, they focus their attentions on our conclusion that for our system (i.e., seven polymers and...

Single Carrier Frequency Division Multiple Access (SC-FDMA) has been adopted for 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) uplink communication since it combines the low peak to average power ratio feature of single-carrier transmission systems with the multipath resistance and flexible frequency allocation of orthogonal frequency-division multiple access (OFDMA). Unfo...

BACKGROUND Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine, and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) enzyme activity have an extreme sensitivity to this drug as a result of the accumulation of higher cellular concentrations of thioguanine nucleotides. We studied the metabolism, dose requirements, and tolerance of 6-mercapto...

Imagine an area the size of US state Rhode Island, some 3000 km2, breaking off from land, collapsing, and floating away. Picture Brown University completely submerged houses falling into Atlantic Ocean. Luckily for residents Providence rest state, Island is a relatively stable land mass, so such collapse unrealistic scenario. But if it were built on Antarctic ice shelf, story would be little di...

We read with attention the recently published article by de Jong et al1De MJ, al. Clin Gastroenterol Hepatol 2020 Apr 23;S1542-3565(20)30535-30538.Google Scholar about cost-effectiveness analysis of telemedicine-directed specialized versus standard care for patients inflammatory bowel diseases (IBD). The authors in 2017 largest multicenter clinical trial evaluating telemedicine IBD, enrolling a...

INTRODUCTION In 2011, some 3800 Rural Health Clinics (RHCs) delivered primary care in underserved rural areas throughout the USA. To date, little research has been conducted to identify the variability in RHC performance. In an effort to address the knowledge gaps, a national, longitudinal study was conducted of a panel of 3565 RHCs. The goals of the study were to determine: (1) the relationshi...

The occupancy by lorazepam of the benzodiazepine binding site of rat brain GABAA receptors was compared when measured using either in vivo binding of [H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) in terminal studies or [C]flumazenil binding in anesthetized animals assessed using a small animal positron emission tomography ...

The absorption of gabapentin (Neurontin) is dose-dependent and variable between patients. Rapid clearance of the drug necessitates dosing three or more times per day to maintain therapeutic levels. These deficiencies appear to result from the low capacity, limited intestinal distribution, and variable expression of the solute transporter responsible for gabapentin absorption. Saturation of this...

Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X3, P2X2/3, P2X4 and P2X7, and P2Y (e.g., P2Y2) receptors, can modulate...