Skeletal and cardiac muscles are remarkable biological machines that support and move our bodies and power the rhythmic work of our lungs and hearts. As well as producing active contractile force, muscles are also passively elastic, which is essential to their performance. The origins of both active contractile and passive elastic forces can be traced to the individual proteins that make up the...

Resistance training evokes myocardial adaptation; however, the effects of a single resistance exercise session on cardiac performance are poorly understood or investigated. This study aimed to investigate the effects of a single resistance exercise session on the myocardial contractility of spontaneously hypertensive rats (SHRs). Male 3-month-old SHRs were divided into two groups: control (Ct) ...

BACKGROUND We hypothesized that S100A1 is regulated during human hypertrophy and heart failure and that it may be implicated in remodeling after left ventricular assist device. S100A1 is decreased in animal and human heart failure, and restoration produces functional recovery in animal models and in failing human myocytes. With the potential for gene therapy, it is important to carefully explor...

Cardiac parasympathetic activity was assessed using 24 hour electrocardiographic recordings by measuring the incidence of larger changes in successive RR intervals, which in normal subjects occur frequently but irregularly. In 25 normal subjects the mean number of times per hour in which the change in successive RR interval was greater than 50 ms was 150-250 during waking and 350-450 during sle...

Pharmacovigilance is the subject that deals with the detection, assessment, understanding, and prevention of adverse effects of drugs, or any other drug-related problems. Ecopharmacovigilance is the science & activity concerning detection, assessment, understanding and prevention of adverse effects or other problems related to the presence of pharmaceuticals in the environment, which affect hum...

The heart of the crustaceans has its own pacemaker neurons inside the heart, which are composed of 9 neurons. The neurons receive innervations of only three kinds of axons originated from the central nervous system; one pair of inhibitory and two pairs of acceleratory axons. Thus, in terms of the neural cardiac control from higher center, this system may have much more simplistic operation comp...

The heart of the crustaceans has its own pacemaker neurons inside the heart, which are composed of 9 neurons. The neurons receive innervations of only three kinds of axons originated from the central nervous system; one pair of inhibitory and two pairs of acceleratory axons. Thus, in terms of the neural cardiac control from higher center, this system may have much more simplistic operation comp...