Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHAMG, the tetra-n-butyl ammonium salt of (p-di-2-chloroethylaminophenyl-beta-D-g...

BACKGROUND Medulloblastoma is the most common malignant brain tumour of childhood. The identification of critical genes involved in its pathogenesis will be central to advances in our understanding of its molecular basis, and the development of improved therapeutic approaches. METHODOLOGY/PRINCIPAL FINDINGS We performed a SNP-array based genome-wide copy number analysis in medulloblastoma cel...

Transforming growth factors beta (TGF-β) are multi-functional cytokines capable of inducing apoptosis in epithelial cells, including glomerular podocytes. We and others have previously shown that podocyte-selective genetic deletion of the microRNA (miR)-processing enzyme, Dicer, caused glomerulosclerosis that was associated with podocyte apoptosis, and the miR-30 family was implicated in the pr...

Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypoth...

BACKGROUND AND THE PURPOSE OF THE STUDY Budesonide is the drug of choice for treatment of active inflammatory bowel disease (IBD). The aim of this study was to develop budesonide pellets based on a novel colon drug delivery system (CODES). METHODS Pellet cores containing lactulose or mannitol were prepared by extrusion/spheronization and coated with an acid soluble polymer (Eudragit E100), hy...

The aim of the present study was to investigate the effect of Ammonio Methacrylate Copolymer Dispersion Type A (Eudragit RL 30 D) and Ammonio Methacrylate Copolymer Dispersion Type B (Eudragit RS 30 D) combination in different weight ratios on the release kinetics of Ambroxol Hydrochloride from coated pellets. Microcrystalline cellulose, lactose, maize starch, hydroxypropyl methylcellulose and ...

Flavor sensation is one of the most prevalent characteristics food industries and an important consumer preference regulator dairy products. So far, many volatile compounds have been identified, their molecular mechanisms conferring overall flavor formation reported extensively. However, little known about critical compound a specific sensory in terms oxidized off-flavor perception. Therefore, ...

NIMET DIAMOND ADATIA Fracture Resistance And Surface Treatment Of Y-TZP Prepable Ceramic Abutments and Bars. (Under the direction of Dr. Stephen Bayne) Intraoral preparation of zirconia implant abutments creates deep surface defects making abutments susceptible to fracture during loading. Fracture strengths were tested for (1) HIP-processed zirconia bars (Astra-Tech) after preparation and/or su...