In the present study, we investigated the 3' untranslated region (UTR) of the mouse core clock gene cryptochrome 1 (Cry1) at the post-transcriptional level, particularly its translational regulation. Interestingly, the 3'UTR of Cry1 mRNA decreased its mRNA levels but increased protein amounts. The 3'UTR is widely known to function as a cis-acting element of mRNA degradation. The 3'UTR also prov...

conclusions sequence and structural diversity of the 3'utr variable region and poly u/uc region found in the local isolates indicate specificity in the regulating elements of 3'utr that might be associated with differential replication efficacy of the hcv pakistani isolates. the study necessitates functional characterization of these regulating elements to elucidate variable viral eff...

Ste20-like kinase, SLK, a germinal center kinase found in kidney epithelial cells, signals to promote apoptosis. Expression of SLK mRNA and protein and kinase activity are increased during kidney development and recovery from ischemic acute renal failure. The 3'-untranslated region (3'-UTR) of SLK mRNA contains multiple adenine and uridine-rich elements, suggesting that 3'-UTR may regulate mRNA...

Most of the beta thalassaemia cases are heterogeneous at molecular level. The genetic variation arises due to mutation a single beta-globin gene (HBB) on chromosome 11p15.5. Eventhough, basis and natural history this disorder still not well understood clinical presentation in certain patients was always correlated with diagnosis [1].
 
 study aimed evaluate predisposing effect HBB pol...

OBJECTIVES OCT4 is a transcription factor required for pluripotency during early embryogenesis and the maintenance of identity of embryonic stem cells and pluripotent cells. Therefore, the effective expression regulation of this gene is highly critical. UTR regions are of great significance to gene regulation. In this study, we aimed to investigate the potential regulatory role played by 5´UTR ...