background and objectives: bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bac- terial compounds such as some thiazole and imidazole derivatives. thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on bacillus cereus , listeria monocytogenes , escherichia coli, salmonella typhimurium...

Aq4{5-Nitro-2-furyl)-2-thiazolyl]acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. 7V-[4-(5-Nitro-2-fury...

ABSTRACT. The versatile scaffold, N'-(2-cyanoacetyl)-2-hydroxybenzohydrazide (3) was utilized in the production of new pyridine, chromene and thiazole derivatives as antimicrobial antioxidant agents. synthetic strategy involves treatment precursor 3 with various arylidene-malononitrile 3-aryl-2-cyanoacrylate compounds to furnish substituted pyridines 5 7. interaction salicylaldehyde and/or phen...

imidazo[2,1-b]thiazoles are obtaind in excellent yields from the addition reaction between thiohydantoin and ethylbromopyruvate.  these imidazo[2,1-b]thiazoles in the presence of p-tsa in boiling toluene refluxed for 2.5 hours led to imidazo[2,1-b]thiazole-3-carboxylates in elimination reactions

Glycine was found to replace thiamine thiazole for the growth of the thiazoleless mutant of Escherichia coli; it also stimulated the production of thiamine thiazole by washed cell suspensions of the mutant.

Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, using a cell-based assay system we identified thiazole antibiotic Siomycin A as an inhibitor of FoxM1 transcriptional activity. Here, we report that structurally similar thiazole antibiotic, thiostrep...

Fascin has recently emerged as a potential therapeutic target, as its expression in cancer cells is closely associated with tumor progression and metastasis. Following the initial discovery of a series of thiazole derivatives that demonstrated potent antimigration and antiinvasion activities via possible inhibition of fascin function, we report here the design and synthesis of 63 new thiazole d...

Thiamine pyrophosphate is required as a coenzyme for several enzymatic reactions which result in the decarboxylation of cu-keto acids with the concomitant formation of corresponding aldehydes or their condensation products (a-keto alcohols). A number of investigators (l-3) have found that thiamine will catalyze the same reactions under mildly alkaline conditions in the absence of enzymes. This ...