Treatment of 4-heptafluoroisopropyl-2-methoxy-3,5,6-trifluropyridine (4 ) with aqueous ammonia in THF gave 2-amino-3,5-difluoro-4-heptafluoroisopropyl- 6-methoxy pyridine (5) in 7 1% yield. Chlorination of this amine with 'ButOCl at -16°C gave an unstable product, namely 2-dichloroarnino-3,5- difluoro-4-heptafluoroisopropyl-6-methoxy pyridine (6). Iodine-catalysed rearrangement of this dic...

In the title dinuclear compound, [Zn(2)(C(6)H(6)N(3)O)(2)(C(6)H(7)N(3)O)(2)](NO(3))(2), the Zn(II) cation is N,N'-chelated by one pyridine-2-carboxamide oximate anion and one pyridine-2-carboxamide oxime mol-ecule, and is further bridged by an oxime O atom from the adjacent pyridine-2-carboxamide oximate anion, forming a distorted trigonal bipyramidal coordination. Two pyridine-2-carboxamide ox...

1. Inhibition by pyridine of reduction of NAD by ethanol in the presence of yeast alcohol dehydrogenase was studied at 25 degrees in 60mm-glycine buffer (K(+), pH9.3). 2. The apparent Michaelis constant for ethanol increases linearly and that for NAD increases non-linearly with pyridine concentration. 3. Rates, v, observed in the presence of pyridine are lower than the values calculated from th...


 ABSTRACT. A novel series of mononuclear complexes the type, [M(L)(H2O)2] [M = Co(II) (1), Ni(II) (2), Zn(II) (3), Cd(II) (4), L dipicolinate), has been investigated using various techniques, including elemental analyses, FT-IR, 1H- and 13C NMR spectroscopy, powder XRD thermogravimetric analysis. The results indicate that coordination dipicolinic acid to metal ions involves two carboxylat...

The syn theses of diaquabis (3-hydroxyflavonato) cobalt (II) and bis(pyridine) bis (3hydroxyflavonato)cobalt(II) are described. Results from infrared spectra clearly show that the 3-hydroxyflavonato anion forms a chelate through the 3-hydroxy 4-keto groups. The electronic spectra of both complexes indicate that cobalt(II) has an octahedral geometry. Quantitative analyses of the isolated product...

Several new 2,6-bis(substituted)pyridine ligands and 2,6-bis(substituted)pyridine Ag(I) nitrate complexes were synthesized and characterized spectroscopically. The newly synthesized ligands include pyridine-2,6-bis(3-oxopropanenitrile) (1), pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (2), and pyridine-2,6-bis((E)-2-(2-phenylhydrazono)-3-oxopropanenitrile) (3). The newly synthesized...

Electrophilic aromatic substitution reactions of pyridines are extraordinarily challenging. Instead of C-substitution at the pyridine ring, the electrophile typically forms an adduct with the pyridine nitrogen, which even further deactivates the already electron deficient pyridine ring toward electrophilic substitution. For example, the direct nitration of pyridine may require a reaction temper...

It has been shown previously that the diphosphopyridine nucleotidase from pig brain is capable of catalyzing an exchange reaction between various substituted pyridine compounds and diphosphopyridine nucleotide to form analogues of diphosphopyridine nucleotide (l-4). The variation in reactivity of the various analogues prepared in this manner indicates the importance of the grouping in position ...