نتایج جستجو برای: 28b
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In the 'Introduction' and 'Results and Discussion' sections of this manuscript, the authors used 2 sequences that were previously published and cited already as references 35 and 44. To better reflect the use of these sequences within the Introduction: " Using these dependencies, we designed Ag-DNA templates to function as an optical sensor in living cells' interior environments (Fig. 1b–d) (fo...
MicroRNA-122 (miR-122) facilitates hepatitis C virus replication in vitro. Serum miR-122 has been implicated as a biomarker for various liver diseases; however, its role in chronic hepatitis C remains unclear. To address this issue, 126 patients with chronic hepatitis C who completed pegylated IFN plus ribavirin therapy with sustained virologic response (SVR) or nonresponse (NR) were retrospect...
The interleukin 28B (IL-28B) rs12979860 C/T polymorphism is a predictor of spontaneous and treatment-induced hepatitis C virus (HCV) clearance. The C/C genotype is associated with higher serum cholesterol, predictor of a favorable outcome in chronic hepatitis C. Whether IL-28B polymorphism and serum cholesterol play a role in modulating the history of mild hepatitis C is unknown. To clarify thi...
BACKGROUND & AIMS In patients with chronic hepatitis C who failed to respond to standard therapy, high-dose pegylated interferon (IFN)-α and/or ribavirin could induce a stronger antiviral response and prevent treatment failure and HCV resistance when combined with direct-acting antivirals. The influence of genetic determinants in this context remains unknown. METHODS Eighty-three patients inf...
The plasmid vector pET-28b(+) named “Young” was produced according a work of 2014.1 This construct is designed to allow the expression 13.6 kDA protein with C-terminal 6histag. It supposed be an anti-HRP (Horse-radish peroxydase protein). not expressed in first E. coli: we attempt explain this phenomenon.
Host genetic factors may predict the outcome and treatment response in hepatitis C virus (HCV) infection. One of these factors is the single nucleotide polymorphisms of the interleukin 28B (IL28B) gene. We sought to evaluate the outcome of pegylated interferon and ribavirin therapy in association with IL-28B rs8099917 and rs12980275 in patients infected with HCV genotype 4. A total of 180 patie...
We examined the association of the interleukin-28B (IL-28B) gene rs12979860 T/C polymorphism with development of hepatitis virus-related hepatocellular carcinoma (HCC) and liver cirrhosis (LC). Two investigators independently searched the PubMed, Elsevier, EMBASE, Web of Science, Wiley Online Library, and Chinese National Knowledge Infrastructure data bases. Pooled odds ratios (ORs) and 95% con...
سابقه و هدف: فاکتورهای ژنتیکی، عوامل محیطی و فاکتورهای مرتبط با ویروس hcv نقش مهمی در پیشرفت بیماری هپاتیت c دارند. این مطالعه با هدف ارزیابی ارتباط واریانت های ژنتیکی حاصل از پلی مورفیسم il-28b در بیماران مبتلا به عفونت مزمن hcv در مقایسه با افراد شاهد انجام گرفت. مواد و روش ها: در این مطالعه مورد- شاهدی 133 بیمار مبتلا به hcv مراجعه کننده به مراکز ترک اعتیاد (بیمارستان های زارع ساری و رازی قا...
Host genetic factors may predict the outcome and treatment response in hepatitis C virus (HCV) infection. One of these factors is the single nucleotide polymorphisms of the interleukin 28B (IL28B) gene. We sought to evaluate the outcome of pegylated interferon and ribavirin therapy in association with IL-28B rs8099917 and rs12980275 in patients infected with HCV genotype 4. A total of 180 patie...
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