نتایج جستجو برای: 2515
تعداد نتایج: 114 فیلتر نتایج به سال:
P-glycoprotein (Pgp) is a plasma membrane protein whose overexpression confers multidrug resistance to tumor cells by extruding amphipathic natural product cytotoxic drugs using the energy of ATP. An elucidation of the catalytic cycle of Pgp would help design rational strategies to combat multidrug resistance and to further our understanding of the mechanism of ATP-binding cassette transporters...
PURPOSE CHOICE (CHanges to treatment and Outcomes in patients with type 2 diabetes initiating InjeCtablE therapy) assessed patterns of exenatide bid and initial insulin therapy usage in clinical practice in six European countries and evaluated outcomes during the study. METHODS CHOICE was a 24-month, prospective, noninterventional observational study. Clinical and resource use data were colle...
OBJECTIVES To investigate policies on neonatal vitamin K and their implementation. DESIGN Two phase postal survey. SETTING United Kingdom. PARTICIPANTS A 10% random sample of midwives registered with the United Kingdom Central Council for nursing, midwifery, and health visiting. Of 3191 midwives in the sample, 2515 (79%) responded to phase one and 2294 (72%) completed questionnaires on th...
OBJECTIVE Oesophageal adenocarcinoma (OA) incidence has risen sharply in Western countries over recent decades. Local and systemic inflammation is considered an important contributor to OA pathogenesis. Established risk factors for OA and its precursor, Barrett's oesophagus (BE), include symptomatic reflux, obesity and smoking. The role of inherited genetic susceptibility remains an area of act...
OBJECTIVE We sought to test whether variations across regions in end-of-life (EOL) treatment intensity are associated with regional differences in patient preferences for EOL care. RESEARCH DESIGN Dual-language (English/Spanish) survey conducted March to October 2005, either by mail or computer-assisted telephone questionnaire, among a probability sample of 3480 Medicare part A and/or B eligi...
Boronic acid fluorophore/beta-cyclodextrin complex sensors for selective sugar recognition in water.
A novel boronic acid fluorophore 1/beta-cyclodextrin (beta-CyD) complex sensor for sugar recognition in water has been designed. The probe 1 bearing pyrene moiety as a fluorescent signal transducer exhibits no fluorescence emission, due to its aggregation in water containing 2% DMSO; however, the addition of beta-CyD to this solution largely changes UV-vis and fluorescence spectra of 1 by formi...
This paper demonstrates how several important results in environmental economics, true under mild conditions in closed economies, are false or need serious amendment in a world with international trade in goods. Since the results we highlight have framed much of the ongoing discussion and research on the Kyoto protocol, our viewpoint from trade theory suggests a re-examination may be in order. ...
BACKGROUND The pathophysiology of low flow, low gradient severe aortic stenosis (LGSAS) with preserved ejection fraction is poorly understood. It has been proposed that abnormalities of arterial circulation are a major contributor to this syndrome. METHODS AND RESULTS We invasively examined systemic arterial afterload (effective arterial elastance, Ea; total arterial compliance, Ca; and syste...
OBJECTIVE To determine how much of the variation in physician group profiling for asthma care can be attributed to physician groups and how reliable those profiling indicators are. STUDY DESIGN Cross-sectional study. Variations attributable to physician groups are presented using the intraclass correlation coefficient (ICC). The reliability of profiling results was determined using the ICC an...
OBJECTIVES Racial and ethnic minorities are at increased risk for hypertension and hypercholesterolemia. Appropriate blood pressure and cholesterol monitoring is a critical first step in identification, treatment, and control of these conditions and the prevention of coronary artery disease. This study examines blood pressure and cholesterol monitoring among non-Hispanic Black, Hispanic, and no...
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