The permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs [acyloxyalkoxy-based cyclic prodrug of DADLE (AOA-DADLE), coumarinic acid-based cyclic prodrug of DADLE (CA-DALE), and oxymethyl-modified coumarinic acid-based cyclic prodrug of DADLE (OMCA-DADLE)] across the blood-brain barrier (BBB) were determined using an in situ perfused ...

Intramural gradients of intracellular Ca(2+) (Ca(i)(2+)) Ca(i)(2+) handling, Ca(i)(2+) oscillations, and Ca(i)(2+) transient (CaT) alternans may be important in long-duration ventricular fibrillation (LDVF). However, previous studies of Ca(i)(2+) handling have been limited to recordings from the heart surface during short-duration ventricular fibrillation. To examine whether abnormalities of in...

BACKGROUND Oligodendrocytes, the myelinating glial cells of central nervous system, are highly vulnerable to ischemic-induced excitotoxic insult, a phenomenon in which calcium overload triggers cell death. Berberine is an alkaloid extracted from medicinal herbs as Coptidis Rhizoma with several pharmacological effects like inhibition of neuronal apoptosis in cerebral ischemia. METHODS We exami...

Post-rest contractile behavior of isolated myocardium indicates the capacity of the sarcoplasmic reticulum (SR) to store and release Ca2+. We investigated post-rest behavior in isolated muscle strips from nonfailing (NF) and endstage failing (dilated cardiomyopathy [DCM]) human hearts. At a basal stimulation frequency of 1 Hz, contractile parameters of the first twitch after increasing rest int...

S OF PAPERS PUBLISHED April 1, 2001 – March 31, 2002 Isoscalar Giant Resonances in Si and the Mass Dependence of Nuclear Compressibility D. H. Youngblood, Y. -W. Lui, and H. L. Clark Phys. Rev. C 65, 034302 (2002) The giant resonance region from 8 MeV<Ex<55 MeV in Si has been studied with inelastic scattering of 240 MeV α particles at small angles including 0°. Strength corresponding to 81±10%,...

A sequence of four phases has been found for an acetonitrile-solvated co-crystal with 15-crown-5 of the nickel complex [acetonitrilediaqua-κ(1)O-nitrato-κ(2)O-nitratonickel(II)]. The structure could be determined at intervals of ca 10 K in the range 90-273 K because crystals remain single through the three transitions. In phase (I) (T ≥ ca 240 K; P2(1)/m, Z' = ½), there is extensive disorder, w...

BACKGROUND Congestive heart failure (CHF) is frequently associated with atrial fibrillation (AF), but little is known about the effects of CHF on atrial cellular electrophysiology. METHODS AND RESULTS We studied action potential (AP) properties and ionic currents in atrial myocytes from dogs with CHF induced by ventricular pacing at 220 to 240 bpm for 5 weeks. Atrial myocytes from CHF dogs we...

Large-conductance Ca-dependent K channels (KCa), which are abundant on the sarcolemma of vascular myocytes, provide negative feedback via membrane hyperpolarization that limits Ca entry through L-type Ca channels (ICaL). We hypothesize that local accumulation of subsarcolemmal Ca 21 during ICaL openings amplifies this feedback. Our goal was to demonstrate that Ca entry through voltage-gated ICa...

1. Lincoff H, Lopez R, Kreissig I, Yannuzzi L, Cox M, Burton T. Retinoschisis associated with optic nerve pits. Arch Ophthalmol. 1988;106:6167. 2. Spaide RF, Costa DL, Huang SJ. Macular schisis in a patient without an optic disk pit optical coherence tomographic findings. Retina. 2003; 23:238-240. 3. Rutledge BK, Puliafito CA, Duker JS, Hee MR, Cox MS. Optical coherence tomography of macular le...

The apparent calcium (Ca) digestibility coefficient (ADC) and true (TDC) of different inorganic sources were determined in laying hens ages. Three Ca tests carried out, each assessing 240 Lohmann Brown lineage distributed a completely randomized design. Nine dietary treatments arranged 3 × factorial design consisting three ages (40, 50 70 weeks) (dicalcium phosphate (DCP) sources, fine (FL) coa...