sinonasal teratocarcinosarcoma (sntcs) is a rare tumor characterized by mixture architecture of epithelial and mesenchymal components. sntcs is a highly malignant tumor displaying progressive and aggressive growth with poor prognosis. only about 40% of all patients survive after five years. it seems the combination of surgery and radiotherapy currently is the most effective treatment. in this r...

We investigated the role of the cdk inhibitor protein p21(Cip-1/WAF1/MDA6) (p21) in the ability of MAPK pathway inhibition to enhance radiation-induced apoptosis in A431 squamous carcinoma cells. In carcinoma cells, ionizing radiation (2 Gy) caused both primary (0-10 min) and secondary (90-240 min) activations of the MAPK pathway. Radiation induced p21 protein expression in A431 cells within 6 ...

The ESHO protocol 3-85 is a multicentre randomized trial investigating the value of hyperthermia as an adjuvant to radiotherapy in treatment of malignant melanoma. A total of 134 metastatic of recurrent malignant melanoma lesions in 70 patients were randomized to receive radiotherapy alone (3 fractions in 8 days) or each fraction followed by hyperthermia (aimed for 43 degrees C for 60 min). Rad...

PURPOSE Radiation remains a mainstay for the treatment of nonmetastatic head and neck squamous cell carcinoma (HNSCC), a malignancy characterized by a high rate of PI3K/mTOR signaling axis activation. We investigated the ATP-competitive dual PI3K/mTOR inhibitor, PF-05212384, as a radiosensitizer in preclinical HNSCC models. EXPERIMENTAL DESIGN Extent of radiation enhancement of two HNSCC cell...

gamma rays pose enough energy to remove electrons from atoms of absorbing material including human body and adversely affect human health. the external exposure of human beings to natural environmental gamma radiation normally exceeds that from all man-made sources combined. therefore, we monitored gamma dose rate in indoor environments and estimated corresponding annual effective dose in selec...

The goals of this study were to evaluate the effects of ionizing radiation on apical junctions in colonic epithelium and mucosal barrier function in mice in vivo. Adult mice were subjected to total body irradiation (4 Gy) with or without N-acetyl-l-cysteine (NAC) feeding for 5 days before irradiation. At 2-24 h postirradiation, the integrity of colonic epithelial tight junctions (TJ), adherens ...

 The radiation hardness of diode array devices based on silicon on insulator technology and bulk technology was investigated. The devices were exposed to 24 GeV/c protons (at CERN) up to a fluence of 4.1 10 p/cm. Charge collection following irradiation indicated a significant reduction in minority carrier lifetime. The damage constant was calculated using alpha particle spectroscopy methods. T...

BACKGROUND It is recognized that UV radiation produced apoptotic cells (sun burn cells) in the epidermis of mice. However, the relationship between apoptosis and cell proliferation after UV exposure in the skin of hairless mice are still unclear. OBJECTIVE To investigate the effects of ultraviolet (UV) radiation on molecular events associated with apoptosis and proliferation in SKH1-hr mouse ...