In just 10 years from its discovery in 2000, interleukin-23 has quickly moved from being recognized as a pro-inflammatory cytokine to a key player and potential therapeutic target in psoriasis.

The set of all permutations, ordered by pattern containment, forms a poset. This paper presents the first explicit major results on the topology of intervals in this poset. We show that almost all (open) intervals in this poset have a disconnected subinterval and are thus not shellable. Nevertheless, there seem to be large classes of intervals that are shellable and thus have the homotopy type ...

introduction: in this paper, a novel complexity measure is proposed to detect dynamical changes in nonlinear systems using ordinal pattern analysis of time series data taken from the system. epilepsy is considered as a dynamical change in nonlinear and complex brain system. the ability of the proposed measure for characterizing the normal and epileptic eeg signals when the signal is short or is...

Let C be a conjugation class of permutations of a finite field Fq. We consider the function NCðqÞ defined as the number of permutations in C for which the associated permutation polynomial has degree 5q 2. In 1969, Wells proved a formula for N1⁄23 ðqÞ where 1⁄2k denotes the conjugation class of k-cycles. We will prove formulas for N1⁄2k ðqÞ where k 1⁄4 4; 5; 6 and for the classes of permutation...

The recent advances in the understanding of psoriasis pathogenesis have clarified the pivotal role of interleukin (IL)-23. It is a heterodimeric cytokine consisting of two subunits, the unique p19 and the p40, which are shared with IL-12. The basic role of IL-23 in psoriasis is the activation and maintenance of the T-helper 17 pathway. New research findings indicate that IL-23 is more important...

We show how to onstru t pseudo-random permutations that satisfy a ertain y le restri tion, for example that the permutation be y li ( onsisting of one y le ontaining all the elements) or an involution (a self-inverse permutation) with no xed points. The onstru tion an be based on any (unrestri ted) pseudo-random permutation. The resulting permutations are de ned su in tly and their evaluation a...