MicroRNAs (miRNAs) are a cluster of short non-coding RNAs playing critical roles in human cancers. miR-187 was recently found to be a novel cancer-related microRNA. However, the expression and function of miR-187 in cervical cancer have not been investigated. In this study, we found that miR-187 level was decreased in cervical cancer tissues and cell lines. Patients with low level of miR-187 ha...

MicroRNA-221 and microRNA-222 (miR-221/222) have been identified as oncogenes and confirmed to be overexpressed in various types of cancer. However, the regulation mechanism of miR-221/222 in oral squamous cell carcinoma (OSCC) remains to be fully elucidated. Previously, an miR-221/222 sponge was successfully constructed and its effect on the downregulation of miR-221/222 expression was investi...

(L, L) [95]. (SOp+q, SOp× SOq) [201]. (Sp2n, O(V )) [477]. ∗ [157, 360]. 1 [111]. 2 [18, 149, 532]. 25 [170]. 3 [429, 105]. 4 [170]. 5 [197, 178, 492]. a [522]. A(G) [501]. Ap(G) [222]. Aθ [248]. א1 [187]. ax + by = cz [324]. b [247]. ( M2(K), t ) [157]. ( Sp(2, R), SL(2, C) ) [135]. modp [312]. C∗ [207, 59, 321, 360, 260, 63, 280, 380, 70, 101, 94, 304, 80, 363, 109]. C [148]. CAR [129]. CAT(0...

Increased miR-222 levels are associated with a poor prognosis in patients with bladder cancer. However, the role of miR-222 remains unclear. In the present study, we found that miR-222 enhanced the proliferation of both the T24 and the 5637 bladder cancer cell lines. Overexpression of miR-222 attenuated cisplatin-induced cell death in bladder cancer cells. miR-222 activated the Akt/mTOR pathway...

(L, L) [95]. (SOp+q, SOp× SOq) [201]. (Sp2n, O(V )) [477]. ∗ [157, 360]. 1 [111]. 2 [18, 149, 532]. 25 [170]. 3 [429, 105]. 4 [170]. 5 [197, 178, 492]. a [522]. A(G) [501]. Ap(G) [222]. Aθ [248]. א1 [187]. ax + by = cz [324]. b [247]. ( M2(K), t ) [157]. ( Sp(2, R), SL(2, C) ) [135]. modp [312]. C∗ [207, 59, 321, 360, 260, 63, 280, 380, 70, 101, 94, 304, 80, 363, 109]. C [148]. CAR [129]. CAT(0...

microRNAs have been shown to play critical roles in regulating the chemosensitivity of cancer cells. As a member of the oncogenic miRNAs (oncomiRs), miR-222 has been reported to drive the oncogenesis of many types of malignancies. However, little is known concerning the specific role of miR-222 in human oral squamous cell carcinoma (OSCC). The present study explored the role and mechanism of mi...

The miR‑222 cluster has been demonstrated to function as oncomiR in human hepatocellular carcinoma (HCC). miR‑222 confers chemotherapy drug resistance in various cancers, including HCC. However, the effects and mechanisms by which miR‑222 regulates liver tumorigenicity and confers sorafenib (SOR) resistance remain unclear. Here we first investigated the miR‑222 effect on proliferation, cell cyc...

A rising body of evidence suggests that silencing microRNAs (miRNAs) with oncogenic potential may represent a successful therapeutic strategy for human cancer. We investigated the therapeutic activity of miR-221/222 inhibitors against human multiple myeloma (MM) cells. Enforced expression of miR-221/222 inhibitors triggered in vitro anti-proliferative effects and up-regulation of canonic miR-22...

b-Adrenergic receptor blockers (b-blockers) are commonly used to treat heart failure, but the biologic mechanisms governing their efficacy are still poorly understood. The complexity ofb-adrenergic signaling coupled with the influence of receptor polymorphisms makes it difficult to intuit the effect of b-blockers on cardiac physiology. While some studies indicate that b-blockers are efficacious...