نتایج جستجو برای: 206

تعداد نتایج: 8805  

2007
Brian D. Adams Henry Furneaux Bruce A. White

Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of mRNAs. This study examined whether miR-206, previously shown to be elevated in estrogen receptor (ER) -negative breast cancer, regulates the expression of ER . Two putative miR-206 sites, (hER 1 and hER 2), were found in silico within the 3 -untranslated region of human ER mRNA. Transfection of MCF-7 cells w...

2017
Renqiao Tang Feifei Ma Wei Li Shengrong Ouyang Zhuo Liu Jianxin Wu

MicroRNAs (miRNAs) are important post-transcriptional regulators during adipocyte adipogenesis. MiR-206-3p, a tissue-specific miRNA, is absent in white adipocytes. In this study, we examined the roles of mmu-miR-206-3p in the adipogenic differentiation of 3T3-L1 preadipocytes. The miR-206-3p expression has shown an apparent decreasing trend after induction, and sustained low expression througho...

Journal: :International journal of molecular sciences 2016
Xinzheng Jia Huiran Lin Bahareldin Ali Abdalla Qinghua Nie

miRNAs have been widely investigated in terms of cell proliferation and differentiation. However, little is known about their effects on bird growth. Here we characterized the promoter of miR-206 in chicken and found that the preferable promoter was located in 1200 bp upstream of pri-miR-206. In this region, many key transcription factors, including MyoD, c-Myb, CEBPα/β, AP-4, RAP1, Brn2, GATA-...

2016
Manjula Vinod Jay V. Patankar Vinay Sachdev Saša Frank Wolfgang F. Graier Dagmar Kratky Gerhard M. Kostner

Glucose homeostasis is a complex indispensable process, and its dysregulation causes hyperglycemia and type 2 diabetes mellitus. Glucokinase (GK) takes a central role in these pathways and is thus rate limiting for glucose-stimulated insulin secretion (GSIS) from pancreatic islets. Several reports have described the transcriptional regulation of Gck mRNA, whereas its posttranscriptional mechani...

Journal: :Oncology reports 2015
Xiao-Wei Wang Xue-Qin Xi Jian Wu Yi-Yuan Wan Hong-Xia Hui Xiu-Feng Cao

Colorectal cancer (CRC) is the most common cancer diagnosed worldwide, and the development of metastases is a major cause of mortality. Accumulating evidence suggests that microRNAs are important in carcinogenesis by affecting the expression of genes that regulate cancer progression. A number of studies have shown that miR-206 is frequently downregulated in many human malignancies, including CR...

Journal: :Environmental pollution 2011
Guo-Xin Sun Xin-Jun Wang Qin-Hong Hu

Lead isotopes and heavy metal concentrations were measured in two sediment cores sampled in estuaries of Xiangjiang and Lishui Rivers in Hunan province, China. The presence of anthropogenic contribution was observed in both sediments, especially in Xiangjiang sediment. In the Xiangjiang sediment, the lower (206)Pb/(207)Pb and higher (208)Pb/(206)Pb ratio, than natural Pb isotope signature (1.19...

Journal: :International journal of clinical and experimental medicine 2015
Ya-Jun Zhang Feng Xu Yi-Jie Zhang Hong-Bing Li Ji-Chang Han Lei Li

BACKGROUND MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. miR-206 functions as a tumor suppressor in several cancers. However, its role in non small cell lung cancer (NSCLC) remains unclear. METHODS Expression levels of miR-206 in NSCLC tissues and cell lines were determined by quantitative real-time PCR (qRT-PCR). ...

2016
Kai Yin Wenjin Yin Yaohui Wang Liheng Zhou Yu Liu Gong Yang Jianhua Wang Jinsong Lu

BACKGROUND Previous reports have shown a mutual negative feedback loop between microRNA (miR)-206 and estrogen receptor (ER) expression. Furthermore, decreased miR-206 expression in breast cancer (BC) is associated with the advanced clinical stage and lymph node metastasis. However, its role and the mechanism underlying the migration and invasion of ER positive BC remain unclear. RESULTS In t...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Hiroyuki Inose Hiroki Ochi Ayako Kimura Koji Fujita Ren Xu Shingo Sato Makiko Iwasaki Satoko Sunamura Yasuhiro Takeuchi Seiji Fukumoto Kuniaki Saito Takashi Nakamura Haruhiko Siomi Hiroshi Ito Yoshiyasu Arai Ken-ichi Shinomiya Shu Takeda

Growing evidence shows that microRNAs (miRNAs) regulate various developmental and homeostatic events in vertebrates and invertebrates. Osteoblast differentiation is a key step in proper skeletal development and acquisition of bone mass; however, the physiological role of non-coding small RNAs, especially miRNAs, in osteoblast differentiation remains elusive. Here, through comprehensive analysis...

Journal: :Science 2009
Andrew H Williams Gregorio Valdez Viviana Moresi Xiaoxia Qi John McAnally Jeffrey L Elliott Rhonda Bassel-Duby Joshua R Sanes Eric N Olson

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by loss of motor neurons, denervation of target muscles, muscle atrophy, and paralysis. Understanding ALS pathogenesis may require a fuller understanding of the bidirectional signaling between motor neurons and skeletal muscle fibers at neuromuscular synapses. Here, we show that a key regulator of this signaling is...

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