Diclofenac potassium is a nonsteroidal anti-inflammatory drug and a prostaglandin (PG) synthetase inhibitor. The objective of this study was to develop a spectrophotometric method for the assay of diclofenac potassium. A series of diclofenac potassium solutions were prepared ranging from 200 ppm to 12.5 ppm. After preparation of a standard stock solution of 200 ppm in 100 ml of water, different...

Evaluation of benzene-induced hematotoxicity following exposure to low concentration is important for understanding mechanisms of toxicity and determining the dose response at benzene levels close to the current occupational exposure limit (1 ppm). Male B6C3F1 mice were exposed to 0, 1, 10, 100, or 200 ppm benzene by inhalation for 6 hr/day, 5 days/week, for 1, 2, 4, or 8 weeks. At each samplin...

Cyproconazole, a triazole fungicide, causes hepatocellular adenomas and carcinomas in CD-1 mice at dose levels of 100 and 200 ppm. The constitutive androstane receptor (CAR) has been shown to play a significant role in the overall mode of action for several nongenotoxic rodent carcinogens such as phenobarbital. The liver effects of dietary cyproconazole or phenobarbital were investigated after ...

Clostridium perfringens growth from a spore inoculum was investigated in vacuum-packaged, cook-in-bag, marinated chicken breast that included additional 1.0% NaCl. The packages were processed to an internal temperature of 71.1 °C, ice chilled and stored at various temperatures. The total C. perfringens population was determined by plating diluted samples on tryptose–sulfite–cycloserine agar fol...

Hydrous melting driven by changes in H2O storage capacity may occur in a variety of settings in the mantle, including in oceanic basalt sources and in deeper regions above and below the transition zone. The 50–200 ppm H2O in the upper mantle likely derives from a blend of sources that may include residues of hydrous partial melting, either in the deep mantle and/or beneath arcs or oceanic islan...

Leaves of Artemisia annua linn. and Azadirachta indica were extracted in petroleum ether and hexane respectively by different methods of extraction i.e. cold extraction, reflux extraction and soxhlet extraction. The crude extract obtained was tested against third instar larvae of Anopheles stephensi. On comparison of larval mortality of crude extract obtained by these three methods, both soxhle...

Mallard ducks were fed diets containing various levels of technical DDT or chemically pure p,p'-DDT, or dieldrin. Either technical DDT or p,p'-DDT at 20 ppm or greater, or dieldrin at I 0 ppm caused a statistically significant reduction in e9gshell thickness, weight, and calcium. Shells of eggs from ducks fed 40 ppm of p,p -DDT were about 20% thinner than those from control ducks, and shells of...

PURPOSE 1-Bromopropane (1-BP) intoxication is associated with depression and cognitive and memory deficits. The present study tested the hypothesis that 1-BP suppresses neurogenesis in the dentate gyrus, which is involved in higher cerebral function, in adult rats. METHODS Four groups of 12 male Wistar rats were exposed to 0, 400, 800, 1000 ppm 1-BP, 8 h/day for 7 days. Another four groups of...