The relationship between hypothyroidism and disturbance of the hypothalamo-hypophysial-adrenal axis was investigated using adult male rats. Hypothyroidism was produced by administration of 4-methyl-2-thiouracil (thiouracil) in the drinking water for 2 weeks. Hypothyroidism decreased adrenal weights to 57% of controls and plasma concentrations of corticosterone to 48% of controls. The changes in...

Rats fed on atherogenic diets containing 2% cholesterol and 0.5% cholic acid with or without 0.15% thiouracil were exposed to carbon disulphide (CS2) vapours (1 mg/l of air), five hours a day, six days a week for 6-10 months. Serum and aorta lipid contents were determined, and the extent of atherosclerotic changes was investigated. The following effects of chronic exposure to CS2 were found: (1...

T HE role of the thyroid gland in the regulation of general body metabo, [ism, metamorphosis, growth, and development is well known.The in. fluence of the thyroid gland and its hormone, thyroxine, upon the amount and distribution of body fat is not thoroughly understood. Although obesity is frequently associated with hypothyroidism in the human, this is not always the case and some hypothyroid ...

Previous studies of the hypothalamus-pituitary-adrenal (HPA) axis in young rodents have found thiouracil-induced hypothyroidism to delay development of the axis past a relative stress non-responsive period. Little attention has been paid to the effects of long-term hypothyroidism on the function of this axis. The present study examined HPA axis response to an acute stress as determined by produ...

By using a highly specific radioimmunoassay the formation of tri-iodothyronine by the deiodination of thyroxine was studied in rat liver homogenate. Several observations suggest that the reaction observed is enzymic in nature. Pre-heating the homogenate for 30 min at 56 degrees C completely abolished conversion of thyroxine into tri-iodothyronine; the component of rat liver homogenate responsib...

A series of 2,5,7-trisubstituted pyrimido[4,5-d]pyrimidine cyclin-dependent kinase (CDK2) inhibitors is designed and synthesized. 6-Amino-2-thiouracil is reacted with an aldehyde and thiourea to prepare the pyrimido[4,5-d]-pyrimidines. Alkylation and amination of the latter ones give different amino derivatives. These compounds show potent and selective CDK inhibitory activities and inhibit in ...