An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabol...

A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2, 3), together with two known compounds (4, 5), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 μM) exhibited significant hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell ...

1. On the basis of its action on a number of conjugated hexuronic acids and other compounds, it is concluded that mouse-liver glucuronidase is specific for f-D-glucopyranuronides, including ,B-D-glucopyranuronic acid-1-phosphate. 2. Derivatives of klevomenthol caused slight activation of glucuronidase. 3. Mouse-liver preparations did not catalyse the condensation of o-aminophenol with aor ,Bglu...

The structural properties of 4-substituted phenols capable of proton-coupled electron transfer (PCET) to superoxide (O2 ) were investigated on the basis of electrochemical and electron spin resonance (ESR) spectral measurements and supported by density functional theory calculations. Although the proton and electron donating abilities of phenols are considered to be important factors in PCET re...

(31 %), m-nitrophenol (9%), p-nitrophenol (9%), m-aminophenol (4%), o-aminophenol (3 %), 4nitrocatechol (0.7 %), aniline (033%) and o-nitrophenol (0.1%). Two new metabolites, nitroquinol (0.1%) and p-nitrophenylmercapturic acid (0.3%), were found in the urine. 4. The denitration products, phenol, catechol, L-phenylmercapturic acid, and trans-tran8-muconic acid, did not occur in the urine. 5. Ni...

The catalytic hydrogenation of p-nitrophenol to p-aminophenol was investigated over alumina supported nickel catalysts prepared by impregnation reduction method and mechanical mixing method. The catalysts were characterized by XRD and FESEM. The results show that the nickel particle diameter of alumina supported nickel prepared by impregnation reduction method (denoted as Ni/Al2O3) is slightly ...

2-p-substituted phenyl-2-benzimidazolo acetonitriles (1a-5a) were prepared by the reaction of benzimidazole , p-substituted benzaldehydes and Sodium cyanide. A series of 2-(α-p -Substituted phenyl-αbenzimidazolo) methyl benzoxazoles (1b-5b) were synthesized by the reaction of 2-p-substituted phenyl-2benzimidazolo acetonitrile(1a-5a) and o-aminophenol in presence of Conc. HCl. These compounds we...