Nano-sized protonated ZSM–5 ( H-ZSM-5nanozeolite) was successfully synthesized by the hydrothermal method using the bagasse ash (BGA) as a new silica source. Cultivated BGA in the south of the Caspian Sea (Mazandaran province, Iran) was used for extracting silica powder. H-ZSM-5 was characterized by Fourier transform infrared (FT-IR), X-ray diffraction (XRD), scanning electronic microscopy (SEM...

A facile and highly efficient protocol was applied successfully to synthesize 4H-pyrimido[2,1,b]benzimiazoles and 4H-pyrimido[2,1,b]benzothiazoles through one-pot three-component cyclocondensation reactions of 2-aminobenzimidazole or 2-aminobenzothiazole with dimedone and aromatic aldehydes in the presence of guanidinium chloride under solvent-free conditions. The reactions us...

In this study, a new mild steel surface pretreatment solution is introduced based on phosphoric acid containing a benzimidazole derivative as inhibitor. In this way, three different benzimidazole derivatives namely benzimidazole BI, 2-methyl benzimidazole 2MBI and 2-aminobenzimidazole 2ABI were studied in the 1M H3PO4 using DC and AC electrochemical techniques. Results revealed the better corro...

Despite the many biological functions of RNA, very few drugs have been designed or found to target RNA. Here we report the results of molecular dynamics (MD) simulations and binding energy analyses on hepatitis C virus internal ribosome entry site (IRES) RNA in complex with highly charged 2-aminobenzimidazole inhibitors. Initial coordinates were taken from NMR and crystallography studies that h...

This study presents the analytical characterisation of a low-cost, selective and sensitive method for inorganic Hg (as Hg22+/Hg2+) determination in liquid matrices based on spectrophotometry. The novelty lies combining pre-concentration i-Hg with spectrophotometry after chelation 2-aminobenzimidazole modified amidic copolymer to increase selectivity sensitivity method. involves ultrasonic extra...

BACKGROUND Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibacterial, antiviral, and antioxidant activity. In addition, the thiophene nucleus has been used in the synthesis of a variety of heterocyclic compounds. RESULTS In the present w...

Many bacteria regulate gene expression through a cell-cell signaling process called quorum sensing (QS). In proteobacteria, QS is largely mediated by signaling molecules known as N-acylated L-homoserine lactones (AHLs) and their associated intracellular LuxR-type receptors. The design of non-native small molecules capable of inhibiting LuxR-type receptors (and thereby QS) in proteobacteria is a...

A structure-guided drug design approach was used to optimize a novel series of aminobenzimidazoles that inhibit the essential ATPase activities of bacterial DNA gyrase and topoisomerase IV and that show potent activities against a variety of bacterial pathogens. Two such compounds, VRT-125853 and VRT-752586, were characterized for their target specificities and preferences in bacteria. In metab...

Antibiotics with novel mechanisms of action are becoming increasingly important in the battle against bacterial resistance to all currently used classes of antibiotics. Bacterial DNA gyrase and topoisomerase IV (topoIV) are the familiar targets of fluoroquinolone and coumarin antibiotics. Here we present the characterization of two members of a new class of synthetic bacterial topoII ATPase inh...