1 Gruppo Fisica Teorica e Matematica Applicata, Unità Tecnico Scientifica Tecnologie Fisiche Avanzate, ENEA-Centro Ricerche Frascati, C.P. 65, Via Enrico Fermi 45, 00044 Frascati, Rome, Italy 2 Dipartimento di Metodi e Modelli Matematici per le Scienze Applicate, Sapienza Università di Roma, Via A. Scarpa 14, 00161 Roma, Italy 3 International Telematic University Uninettuno, Corso Vittorio Eman...

A few analogues of atevirdine or 1-[(5-methoxyindol-2-yl) carbonyl]-4-[3- (ethylamino)-2-pyridyl] piperazine – an anti-HIV belonging to non-nucleoside reverse transcriptase inhibitors were synthesized and evaluated for anti-HIV activity. Replacement of indolyl moiety with 2-alkylthio-1-benzyl-5-imidazolyl substituent afforded 1-[2-(alkylthio-1-benzyl-5-imidazolyl) carbonyl]-4-[3-(isopropylamino...

The structures of new protein farnesyltransferase inhibitors, kurasoins A and B, were elucidated by NMR study. Kurasoins A and B are acyloin compounds having in common a 3-hydroxy-1-phenyl-2-butanone moiety, to which p-hydroxyphenyl and 3-indolyl moieties respectively, are connected at C-4. The structures were confirmed by total synthesis.

Efficient synthesis of bis(indolyl)methanes by the reaction of indole with certain aldehydes and ketones in water afforded the corresponding bis(indolyl)methanes in excellent yields. This reaction has been carried out in the presence of 2 mol% of cerium(IV)triflate at room temperature.

The 3-compact group DI(2) is characterized by cohomology algebra with coefficients in the finite field F3, H∗(BDI(2); F3) = F3[x12, x16], being the rank 2 Dickson algebra. We show that DI(2) is a totally N-determined 3-compact group, compute the endomorphism monoid of DI(2), and investigate subgroups of DI(2).

The title compound, [Al(CH(3))(2)(C(25)H(21)N(2)O)(C(4)H(8)O)], was isolated as a minor component from a reaction mixture of the parent indolyl ligand and trimethyl-aluminum in tetra-hydro-furan. The ligands adopt a distorted tetra-hedral geometry around aluminium. Obvious hydrogen-bonding interactions are not present.