2 2 oxopropylisoindoline 1

alireza aliabadi 1novel drug delivery research center, kermanshah university of medical sciences, kermanshah, iran 2department of medicinal chemistry, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran alireza foroumadi 3department of medicinal chemistry, faculty of pharmacy and pharmaceutical sciences research center, tehran university of medical sciences, tehran, iran ahmad mohammadi-farani 1novel drug delivery research center, kermanshah university of medical sciences, kermanshah, iran.4department of pharmacology, toxicology and medical services, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran mahdi garmsiri mahvar 2department of medicinal chemistry, faculty of pharmacy, kermanshah university of medical sciences, kermanshah, iran5students research committee, kermanshah university of medical sciences, kermanshah, iran

objective(s): alzheimer's disease (ad) is a neurodegenerative disorder in elderly patients. decrease in cholinergic neurotransmission is the main known cause in the pathophysiology of the disease. improvement and potentiation of the cholinergic system could be beneficial for treatment of the ad. acetylcholinesterase inhibitors such as donepezil can enhance the duration of action of acetylc...

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