Purpose N-of-1 trials have been used in medicine to generate treatment information when evidence from randomized controlled trials (RCTs) is not available or applicable. Nof-1 study design maintains the methodological safeguards provided by RCTs (blinding, randomization and controls) yet avoids the disadvantages associated with large trials. A standardized method of reporting of N-of1 trials, s...

The binding of T-1824 (Evans blue) with plasma has been extensively studied in the past by Allen and Orahovats (1) by means of the cellophane sorption method. Although this approach yielded excellent results, a simpler and more direct method seemed desirable. The basis for this new method is furnished by the observation, made in 1939,’ that the free T-1824 gives rise to a distinct polarographic...

an investigation of the incidence of colour defects was made in primary school students. the children ranged in age from 7 to 14 years. the frequencies were 7,04 per cent. for males and 0,53 per cent. for females.

The ability to discriminate pitch changes (or intervals) is foundational for speech and music. In an auditory psychophysical experiment, musicians and non-musicians were tested with fixed- and roving-pitch discrimination tasks to investigate the effects of musical expertise on interval discrimination. The tasks were administered parametrically to assess performance across varying pitch distance...

This paper reports a large-scale direct-test study of absolute pitch (AP) in students at the Shanghai Conservatory of Music. Overall note-naming scores were very high, with high scores correlating positively with early onset of musical training. Students who had begun training at age ≤5 yr scored 83% correct not allowing for semitone errors and 90% correct allowing for semitone errors. Performa...

introduction the mating of related individuals produces an inbred offspring and leads to an increased homozygosity in the progeny, genetic variance decrease within families and increase between families. the ration of homozygosity for individuals was calculated by inbreeding coefficient. inbred individuals may carry two alleles at a locus that are replicated from one gene in the previous genera...