INTRODUCTION A hallmark of systemic autoimmune diseases like systemic lupus erythematosus (SLE) is the increased expression of interferon (IFN) type I inducible genes, so-called IFN type I signature. Recently, T-helper 17 subset (Th17 cells), which produces IL-17A, IL-17F, IL-21, and IL-22, has been implicated in SLE. As CCR6 enriches for Th17 cells, we used this approach to investigate whether...

Psoriasis is the most common chronic inflammatory skin disease in adults, characterized by immune cell infiltration, expansion of disease-associated lymphocytes, and epidermal hyperplasia. Increasing evidence highlights central role interleukin (IL)-17A IL-17F its pathobiology. IL-17A IL-17F, known to be produced activated T helper 17 cells, can form homodimers or heterodimers drive aberrant ke...

1 Medical ProteoScope Co., Ltd., Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 2 Clinical Proteome Center, Tokyo Medical University, Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 3 Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8571, ...

PURPOSE To investigate the association of IL-17F rs763780T>C with cancer risk. MATERIALS AND METHODS We searched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National Knowledge Infrastructure) and WangFang databases until May 2014 for a meta-analysis conducted using RevMan 5.2 software. RESULTS A total of ten papers were included into this meta analysis, involving 3, 3...

1 Clinical Proteome Center, Tokyo Medical University, Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 2 Medical ProteoScope Co., Ltd. Shinjuku-sumitomo Bldg. 17F, 2-6-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 163-0217, Japan 3 Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba,1-1-1 Tenodai, Tsukuba, Ibaraki 305-8571, Japan

Previous studies have suggested a critical role for interleukin IL-17F in innate and adaptive immunity in vivo and its abnormal expression was found to play a bridging role in several neurological disorders. In this study, we investigated the association between functional polymorphisms in IL-17F and Tourette’s syndrome (TS) in a Chinese Han population. We recruited 407 TS nuclear family trios ...

Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL-17A is involved in the development of autoimmunity, inflammation, and tumors, and also plays important roles in the host defens...

Th17 cells are a distinct lineage of effector CD4(+) T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 cells. Similar to IL-17A, IL-22 expression was initiated by transforming growth factor beta signaling in the context of IL-6 and other proinfl...

Salmonella enterica subspecies 1 serovar Typhimurium (S. Typhimurium) causes diarrhea and acute inflammation of the intestinal mucosa. The pro-inflammatory cytokines IL-17A and IL-17F are strongly induced in the infected mucosa but their contribution in driving the tissue inflammation is not understood. We have used the streptomycin mouse model to analyze the role of IL-17A and IL-17F and their...

Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. While it is well-accepted that inflammation is central to NAFLD pathogenesis, the immune pathway(s) orchestrating disease progression are poorly defined. Notably, IL-17RA signaling, via IL-17A, plays an important role in obesity-driven NAFLD pathogenesis. However, the role of the IL-17F, anothe...