نتایج جستجو برای: 166ho

تعداد نتایج: 65  

Journal: :Applied sciences 2022

Background: Transarterial radioembolization (TARE) relies on directly injected 90Y- or 166Ho-loaded microspheres in the hepatic arteries. The activity to be is generally based pre-TARE 99mTc-macro-aggregated-albumin (MAA) imaging, while actual dose distribution post-treatment images. volume of interest (VOIs) propagation methods (i.e., rigid and deformable) from pre- post-TARE imaging might aff...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس - دانشکده پزشکی 1391

نانو و میکروذرات به دلیل دارا بودن ویژگی هایی که ناشی از اندازه ی کوچک آن هاست، پتانسیل بالقوه ای در استفاده ی موفق در تحویل انواع مختلف فرمولاسیون های دارویی از راه های مختلف هستند. مزایای استفاده از میکروذرات عبارتند از: رها سازی کنترل شده ی دارو، محافظت از ترکیبات فعال دارویی و هدف قرار دادن ارگان مورد نظر برای تحویل دارو. میکروسفرهای پلیمری می توانند برای تحویل دارو در یک شیوه ی کنترل شده و...

Ali Bahrami-Samani Amir Reza Jalilian, Maohammad Mazidi Mohammad Ghannadi-Maragheh Reza Bagheri

  Intoduction: Therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. Among some therapeutic radiopharmaceuticals, 166Ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethy...

Ali Bahrami-Samani Amir Reza Jalilian, Hassan Yousefnia, Mehdi Akhlaghi, Mohammad Ghannadi-Maragheh Mohammad Mazidi Samaneh Zolghadri Simindokht Shirvani-Arani,

Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

Journal: :Haematologica 2004
Stefan Knop Bernhard M Dohmen Lothar Kanz Roland Bares Hermann Einsele

Even though high-dose chemotherapy followed by autologous stem cell support has proven superior to conventional treatment, relapse occurs in approximately 75% of patients within five years after autologous transplantation. Initiating salvage treatment after high-dose therapy may be a reasonnable approach with survival time from relapse being more than two years as documented recently. Reported ...

2015
Joong-Sun Kim Kyung-Jin Rhim Won-Seok Jang Sun-Joo Lee Yeonghoon Son Seung-Sook Lee Sunhoo Park Sang Moo Lim

In the present study, the detrimental effect of β-emission on pig skin was evaluated. Skin injury was modeled in mini-pigs by exposing the animals to 50 and 100 Gy of β-emission delivered by (166)Ho patches. Clinicopathological and immunohistochemical changes in exposed skin were monitored for 18 weeks after β-irradiation. Radiation induced desquamation at 2~4 weeks and gradual repair of this d...

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