Nup98 is a glycine-leucine-phenylalanine-glycine (GLFG) repeat-containing nucleoporin that, in addition to nuclear transport, contributes to multiple aspects of gene regulation. Previous studies revealed its dynamic localization within intranuclear structures known as GLFG bodies. Here we show that the mammalian Nup107-160 complex (Y-complex), a major scaffold module of the nuclear pore, togeth...

BACKGROUND AND PURPOSE The risk of atypical fracture of the femur is associated with bisphosphonate use. While characterizing atypical fractures from a previous nationwide study in radiographic detail, we had the impression that the fractures were located either in the subtrochanteric region or in the shaft. We determined whether there is a dichotomy in this respect. PATIENTS AND METHODS The ...

In this article, we propose an improved cryptanalysis of the double-branch hash function standard RIPEMD-160. Using a carefully designed non-linear path search tool, we study the potential differential paths that can be constructed from a difference in a single message word and show that some of these message words can lead to very good differential path candidates. Leveraging the recent freedo...

Taking a kidney biopsy is not a trivial procedure. The sample is almost invariably smaller than the pathologist would like. Investigation usually requires division into even smaller samples to permit the application of specialist techniques. In some cases the biopsy is taken not for diagnosis, but to assess the extent of tissue damage. The clinical need is sometimes extremely urgent. These feat...

Cryptographic hash functions are an important tool in cryptography for applications such as digital fingerprinting of messages, message authentication, and key derivation. During the last five years, several fast software hash functions have been proposed; most of them are based on the design principles of Ron Rivest’s MD4. One such proposal was RIPEMD, which was developed in the framework of t...

In this article, the RIPEMD-160 hash function is studied in detail. To analyze the hash function, we have extended existing approaches and used recent results in cryptanalysis. While RIPEMD and RIPEMD-128 reduced to 3 rounds are vulnerable to the attack, it is not feasible for RIPEMD-160. Furthermore, we present an analytical attack on a round-reduced variant of the RIPEMD-160 hash function. To...

Clinical sign Detection of virus 2016 Jan 8 2016 Feb 3 D/OK D/NE D/OK D/NE 7754 5 y 6 mo <40 <40 40 40 7761 4 y 5 mo <40 <40 80 80 7764 3 y 11 mo <40 <40 160 80 7765 3 y 10 mo <40 <40 <40 <40 7766 3 y 4 mo <40 <40 160 160 7767 3 y 4 mo <40 <40 80 80 Respiratory illness 7768 3 y 4 mo <40 <40 160 160 Respiratory illness Nasal swab RT-PCR (+) 7769 3 y 3 mo <40 <40 320 320 Respiratory illness 7770 ...

Objectif&#160;: La prophylaxie pr&#233;exposition &#171;&#160;PrEP&#160;&#187; est un outil de pr&#233;vention contre le VIH pour les populations &#224; haut risque disponible depuis 2016 en France. De primoprescription CeGIDD ou hospitali&#232;re, renouvellement la PrEP peut &#234;tre assur&#233; m&#233;decine g&#233;n&#233;rale. L&#8217;analyse des freins cette prescription et son suivi g&#23...