Although the idea of teaching integration before di erentiation is certainly not new, most, if not all students are introduced to di erentiation rst. This is certainly the case in our state where many students leave school believing that the de nite integral is an application of antidi erentiation. Primarily for this reason we introduce the de nite integral in our main rst year calculus subject...

MR0199184 (33 #7333) 14.18 Hironaka, Heisuke Resolution of singularities of an algebraic variety over a field of characteristic zero. I, II. Annals of Mathematics. Second Series 79 (1964), 109–203; ibid. (2) 79 (1964), 205–326. Outre la solution d’un problème célèbre, ce travail donne un des outils les plus puissants de la géométrie algébrique. Ce résultat est atteint avec une surprenante écono...

The primary metabolic substrate for the central nervous system (CNS) is glucose. Usual sources of glucose are diet, endogenous production (through gluconeogenesis), and storage (through glycogenolysis). Serum glucose concentrations are relatively tightly controlled by physiologic mechanisms. After dietary sources of glucose are completely used, glycogenolysis is the major physiologic mechanism ...

It is becoming increasingly evident that (a) risk for developmental and degenerative disease increases with more DNA damage, which in turn is dependent on nutritional status, and (b) the optimal concentration of micronutrients for prevention of genome damage is also dependent on genetic polymorphisms that alter the function of genes involved directly or indirectly in the uptake and metabolism o...

Small-molecule inhibition of extracellular proteins that activate membrane receptors has proven to be extremely challenging. Diversity-oriented synthesis and small-molecule microarrays enabled the discovery of robotnikinin, a small molecule that binds the extracellular Sonic hedgehog (Shh) protein and blocks Shh signaling in cell lines, human primary keratinocytes and a synthetic model of human...

The author presents a significant approach to aligning multiple variables inside a cell by applying tabs to the ODS reporting process. Consequently what appeared to be one limitation in classical ODS reporting has been overcome. The technique makes it easy to adopt mixed patterns in presenting the result of proc report, which have become necessary under certain circumstances such as patient pro...

As more horticultural producers in the United States transition to organic production practices, they are challenged in finding consistent and economically viable sources of suitable potting media. Commercial, peat-based media approved for certified organic production are available and custom peat-based mixes that use certified organic fertilizers could also be used. Both of these options, howe...

Mature Plasmodium falciparum parasitized erythrocytes (PE) sequester from the circulation by adhering to microvascular endothelial cells. PE sequestration contributes directly to the virulence and severe pathology of falciparum malaria. The scavenger receptor, CD36, is a major host receptor for PE adherence. PE adhesion to CD36 is mediated by the malarial variant antigen, P. falciparum erythroc...