Rabeprazole sodium (RAB) is an anti-secretory agent which inhibits the enzyme H+/K+ ATPase, present in the stomach parietal cells. The aim of this work is to develop and validate a simple and fast ultraviolet spectrophotometric method (UV) for quantification of RAB in pharmaceutical formulation and compare it with a capillary electrophoresis (CE) one, previously validated. The UV technique was ...

An automated method for esterifying fatty acids in canola oil samples is presented. Using the Agilent 7696A Sample Prep WorkBench, a side-by-side comparison was undertaken comparing a manual method employing automatic pipettors to a method developed for this automated system. Using the Agilent 7696A Sample Prep WorkBench, preparation of 10 samples resulted in 3% RSD for both an acid-catalyzed a...

MicroRNAs (miRNAs) are a group endogenous small non-coding RNAs that inhibit protein translation through binding to specific target mRNAs. Recent studies have demonstrated that miRNAs are implicated in the development of cancer. However, the role of miR-144 in uveal melanoma metastasis remains largely unknown. MiR-144 was downregulated in both uveal melanoma cells and tissues. Transfection of m...

Viruses with genomes larger than 300 kb and up to 1.2 Mb, which encode hundreds of proteins, are being discovered and characterized with increasing frequency. Most, but not all, of these large viruses (often referred to as giruses) infect protists that live in aqueous environments. Bioinformatic analyses of metagenomes of aqueous samples indicate that large DNA viruses are quite common in natur...

Alterations in the expression of microRNAs (miRNAs or miRS) have been implicated in the pathogenesis of the majority of human malignancies, and the dysregulation of microRNA-144 (miR-144) has been associated with several diseases. However, the potential involvement of miR-144 in osteosarcoma, a common malignant bone tumor in children and adolescents with a high risk of relapse and metastasis, h...

(Au-Ag)(144)(SR)(60) alloy nanomolecules were synthesized and characterized by ESI mass spectrometry to atomic precision. The number of Ag atoms can be varied by changing the incoming metal ratio and plateaus at ∼60. UV-vis data demonstrates that the electronic structure of the nanomolecules can be tuned by incorporation of silver atoms. Based on the proposed 3-shell structure of Au(144)(SR)(60...