In the current study, we show that macrophages adaptively resist anthrax lethal toxin (LT) through a toxin-activated process termed toxin-induced resistance (TIR). TIR was triggered by pretreatment of RAW 264.7 or J774A.1 macrophages with a low dose of LT for at least 6 h, which resulted in resistance to high doses of LT for 96 h. Activation of TIR required functional toxin, because LT subunits...

Studies have shown that the basal chordate amphioxus possesses an extraordinarily complex TLR system, including 39 TLRs and at least 40 Toll/IL-1R homologous region (TIR) adaptors. Besides homologs to MyD88 and TIR domain-containing adaptor molecule (TICAM), most amphioxus TIR adaptors exhibit domain architectures that are not observed in other species. To reveal how these novel TIR adaptors fu...

Light is an important limiting factor for the visual foraging process in fishes, and the light regime may potentially affect the competition between visual and tactile predators. We investigated two equal-sized fjords of quite different pelagic food web structure. Earlier studies have revealed that the jellyfish Periphylla periphylla dominates Lurefjorden, while fish predators dominate in the o...

Total internal reflection (TIR) Raman spectroscopy is an experimentally straightforward, surface-sensitive technique for obtaining chemically specific spectroscopic information from a region within approximately 100-200 nm of a surface. While TIR Raman spectroscopy has long been overshadowed by surface-enhanced Raman scattering, with modern instrumentation TIR Raman spectra can be acquired from...

The translation initiation efficiency of a given mRNA is determined by its translation initiation region (TIR). mRNAs are selected into 30S initiation complexes according to the strengths of the secondary structure of the TIR, the pairing of the Shine-Dalgarno sequence with 16S rRNA, and the interaction between initiator tRNA and the start codon. Here, we show that the conversion of the 30S ini...

Large, lightweight, high power, L-band phasedarrays are required to enable future NASA synthetic aperture radar (SAR) missions. The transmit/receive (TIR) module is a key component in SAR antennas and the TIR module efficiency has direct implications on the power dissipation and power generation requirements of the system. Significant improvements in the efficiency of the TIR module will make S...

Space-borne observations of atmospheric methane (CH4) have been made using the Atmospheric Infrared Sounder (AIRS) on the EOS/Aqua satellite since August 2002 and the Thermal and Near-infrared Sensor for Carbon Observation Fourier Transform Spectrometer (TANSOFTS) on the Greenhouse Gases Observing Satellite (GOSAT) since April 2009. This study compared the GOSAT TANSOFTS thermal infrared (TIR) ...

The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-ada...

Myeloid differentiation 88 (MyD88) is the key signaling adapter of Toll-like and interleukin-1 receptors. Recurrent lymphoma-associated mutations, particularly Leu265Pro (L265P), within the MyD88 Toll/interleukin-1 receptor (TIR) domain sustain lymphoma cell survival due to constitutive nuclear factor κB signaling. We found that mutated TIR domains displayed an intrinsic propensity for augmente...

Method for data fusion between Microwave Scanning Radiometer: MSR and Thermal Infrared Radiometer: TIR derived skin sea surface temperature: SSST, wind speed: WS and salinity is proposed. SSST can be estimated with MSR and TIR radiometer data. Although the contribution ocean depth to MSR and TIR radiometer data are different each other, SSST estimation can be refined through comparisons between...