A cross-sectional study was conducted on 1416 women (age: 25 years or more), belonging to Pre and post-menopausal women (1351 & 65 respectively). All subjects were interviewed by using a structured Performa for prevalence of risk factors. Bone mineral density (BMD) was measured to determine the degree of Osteoporosis and Osteopenia by speed of sound (SOS) and broad band ultrasound attenuation (...

Deregulated expression of the type I cytokine receptor, CRLF2, is observed in 5-15% of precursor B-cell acute lymphoblastic leukaemia (B-ALL). We aimed to determine the clinical and genetic landscape of those with IGH-CRLF2 or P2RY8-CRLF2 (CRLF2-r) using multiple genomic approaches. Clinical and demographic features of CRLF2-r patients were characteristic of B-ALL. Patients with IGH-CRLF2 were ...

CONTEXT Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors that modulate gene expression. Therapeutic agents targeting 2 distinct families of PPARs (alpha and gamma) have been introduced in the United States. The first dual-PPAR agonist, muraglitazar, was reviewed by a US Food and Drug Administration (FDA) advisory committee on September 9, 2005, resulting in ...