This study includes synthesis and characterization of new derivatives 3-(2-(6-oxo-1,3-thiazinan-3-yl)-R)-1,3-oxazepane-4,7-dione N-Bromo amines 1,3-oxazepane-4,7-dione derivatives. Schiff's bases reactions through one step process in inert solvents. Some employing [1- 4]; addition, synthesized by the reaction different with (Salicylaldehyde) absolute ethanol under reflux. Heterocyclic rings pre...

The title compound, C(15)H(14)N(2)O(4), is approximately planar, with a dihedral angle of 6.48 (4)° between the amino-methyl-ene unit and the planar five-atom part of the dioxane ring, and a dihedral angle of 2.40 (4)° between amino-methyl-ene unit and the phenyl-ene ring. The dioxane ring is envelope shaped, with the dimethyl-substituted C atom that represents the flap 0.535 (8) Å out of the p...

The cover image is based on the Software Focus AQME: Automated quantum mechanical environments for researchers and educators by Juan V. Alegre-Requena et al., https://doi.org/10.1002/wcms.1663.

4387. 108.Callahan MK, Wolchok JD, Allison JP. Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Semin Oncol 2010; 37: 473-484. (PMID: 21074063) 109.Liakou CI, Kamat A, Tang DN, Chen H, Sun J, Troncoso P, Logothetis C, Sharma P. CTLA-4 blockade increases IFN-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in ca...