a series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4h-1,2,4-triazole was synthesized. the anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (mes) test and rotarod tests with intraperitoneally injected mice. among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4h-1,2,4-triazole (5f) was the most active one and also had...

The intramolecular dipolar cycloaddition of an azide with an alkyne has provided a useful entry into triazole fused tricyclic heterocycles containing both the triazole ring and the oxazolidin-2-one ring system. The requisite azido-alkynes have been prepared via a two-step sequence from fused ring aziridines. A series of 6-12 membered rings containing both the oxazolidinone and triazole rings ha...

Recently, we have enatiospeciflcally synthesized nagstatin (1) and its analogs (for example, 2) having different configurations and functionalities and clarified the structure-activity relationships2 ~ 4). Herein, we describe the synthesis of the triazole analogs (3 and 4) having a triazole ring in place of an imidazole ring, and evaluate their glycosidase inhibitory activities to better unders...

The title compound, C18H20ClN3S, is a functionalized triazoline-3-thione derivative. The benzene ring is almost perpendic-ular to the planar 1,2,4-triazole ring [maximum deviation = 0.007 (1) Å] with a dihedral angle of 89.61 (5)° between them and there is an adamantane substituent at the 3-position of the triazole-thione ring. In the crystal, N-H⋯S hydrogen-bonding inter-actions link the mol-e...

The present work describes the synthesis of a new class glycolipids with systematic variation in linkage region as well aglycon part using Cu(I) catalyzed click reaction. between sugar and was diversified amide, amido-triazole, 5-benzoyl triazole moieties. structural diversity further amplified by incorporating several polar peptide foldamer groups such triazole, peptide, or N-aryl peptoid it. ...

Functional and condensed derivatives of 1,2,4-triazoles are mostly used as biologically active compounds, modern studies increasingly report their successful use surfactants, stabilizers for the formation nanoparticles, components hybrid perovskites, which promising materials opto-electronics.
 Synthesis new [1,3]thiazolo[3,2-b][1,2,4]triazol-7-ium salts containing a long-chain heptadecyl ...

PAPER Thomas Biet and Narcis Avarvari Tetrathiafulvalene mono-and bis-1,2,3-triazole precursors by click chemistry: structural diversity and reactivity The donor ortho-dimethyl-TTF-(N-n-Bu-1,2,3-triazole) 1,5-isomer has been synthesized by click chemistry following a ruthenium-catalyzed azide–alkyne cycloaddition procedure. The single crystal X-ray analysis showed a planar conformation between ...

1-Aryl- and 2-aryl-1,2,3-triazoles were synthesized by N-arylation of the corresponding azoles using aryl iodides. The deprotometalations of 1-phenyl-1,2,3-triazole and -1,2,4-triazole were performed using a 2,2,6,6-tetramethylpiperidino-based mixed lithium-zinc combination and occurred at the most acidic site, affording by iodolysis the 5-substituted derivatives. Dideprotonation was noted from...

Emerging fungi resistant to triazoles are a concern because of the increased use of medical triazoles and exposure to agricultural triazoles. However, little is known about the levels of triazole susceptibility in outdoor airborne fungi making it difficult to assess the risks of inhalation exposure to airborne, antifungal-resistant fungi. This study examined triazole susceptibilities of the air...

BACKGROUND Oral triazole therapy is well established for the treatment of invasive (IPA), allergic (ABPA), and chronic pulmonary (CPA) aspergillosis, and is often long-term. Triazole resistance rates are rising internationally. Microbiological diagnosis of aspergillosis is limited by poor culture yield, leading to uncertainty about the frequency of triazole resistance. METHODS Using an ultras...