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In response to an appropriate stimulus such as phagocytosis of an opsonized particle, macrophages reduce oxygen, first to superoxide anion (O2-), 1 and then to hydrogen peroxide (H202) (1, 2). These metabolites of oxygen are involved in the killing of phagocytosed microorganisms (3). More recently, H202 has also been implicated in macrophage killing of lymphocyte tumor lines (4, 5). Macrophages...
1% in 2000. Although the objective was far from being reached (the current rate being close to 2%), in 2000 Mexico had 53 million inhabitants fewer than it would have had if fertility had remained at its 1970 level. The population pyramids of 1930, 1970 and 2000 clearly illustrate this dynamics (Figure 2). In 1930 the population was beginning to recover from the aftereffects of the Revolution a...
Department of Experimental and Clinical Medicine, Section of Pharmacology and Neuroscience Center (G.C., A.R., F.M., G.M., D.R., E.G., S.Z., D.R., M.M., G.C.) and Department of Pharmaceutical Sciences and Biotechnology Center (R.G., S.S.), University of Ferrara, 44100 Ferrara, Italy. Department of Cardiovascular Sciences, Pharmacology and Therapeutics Group (T.A.B., J.McD., C.P.H., D.G.L.) and ...
TAS-102 significantly improves overall survival in patients with metastatic colorectal cancer. The most common adverse event of TAS-102 is bone marrow suppression, which leads to neutropenia. The incidence of neutropenia is high, and there is no known effective prevention method. Furthermore, the administration method of TAS-102 is complicated. We reported that neutropenia could be avoided by c...
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