Regulatory approval documents contain valuable information, often not published, to assess the drug–drug interaction (DDI) profile of newly marketed drugs. This analysis aimed to systematically review all drug metabolism, transport, pharmacokinetics, and DDI data available in the new drug applications and biologic license applications approved by the U.S. Food and Drug Administration in 2014, u...

Introduction: Studies have shown that middle school is a decisive time for either promoting or dissuading student interest in the areas of mathematics and science (1). Students who are not engaged in learning these subjects in the critical middle school years often lose interest and motivation by the time they reach high school. Use of technology and hands-on activities has been shown to engage...

S S S Chapter One INTRODUCTION ABSTRACT Disasters continue to increase in frequency and affect more and more citizens of the world community. Economic costs are increasing at an alarming rate. The death toll in the last 50 years has been in excess of 12 million persons, billions of people have been “affected”, and economic costs are estimated as high as US$4 trillion. Human and economic costs h...

Correspondence to: Y H Chan Tel: (65) 6317 2121 Fax: (65) 6317 2122 Email: chanyh@ cteru.gov.sg INTRODUCTION Now we are at the last stage of the research process: Statistical Analysis & Reporting. In this article, we will discuss how to present the collected data and the forthcoming write-ups will highlight on the appropriate statistical tests to be applied. The terms Sample & Population; Param...

Given independent samples from P and Q, two-sample permutation tests allow one to construct exact level tests when the null hypothesis is P = Q. On the other hand, when comparing or testing particular parameters θ of P and Q, such as their means or medians, permutation tests need not be level α, or even approximately level α in large samples. Under very weak assumptions for comparing estimators...

ardiac resynchronization therapy (CRT) is an effective reatment for heart failure (HF) for patients who still have ignificant symptoms despite optimal medical therapy. any patients with HF have interventricular and intravenricular conduction delays that cause delayed activation of he lateral wall of the left ventricle (LV). This delayed ctivation leads to ventricular dyssynchrony, which comproi...

En este artículo se presenta una visión general de las implicaciones a la privacidad del uso de las llamadas cripto-monedas, y su principal representante hasta el momento, el Bitcoin. El artículo pretende destacar algunas consideraciones sobre estas tecnologías: la expectativa razonable de privacidad, la seguridad de la información y el posible abuso por parte de los usuarios.

If you take meetings, instant messaging, emails and calls out of your working day there is a fair chance that the remaining work-related communication is relatively small. Most of people’s daily lives is interacting with the social network at the office, engaging with people and using relationships to drive innovation and results. Most individuals would attest to having a good understanding of ...

This lecture—based on the author's book, General Lattice Theory , Birkhäuser Verlag, 1978—briefly introduces the basic concepts of lattice theory, as needed for the lecture " Some combinatorial aspects of congruence lattice representations ". 1.1. Posets. A partially ordered set A; ≤≤ consists of a nonvoid set A and a binary relation ≤ on A such that the relation ≤ satisfies properties (P1)–(P3...