Modification of the innate immune cell environment has recently been recognized as a viable treatment strategy for reducing autoimmune disease pathology. MIS416 is a microparticulate immune response modifier that targets myeloid cells, activating cytosolic receptors NOD2 and TLR9, and has completed a phase 1b/2a trial for the treatment of secondary progressive multiple sclerosis. Using a mouse ...

Previously, we showed that live Salmonella-containing phagosomes (LSP) recruit early acting Rab5 and promote fusion with early endosomes, thus avoiding transport to the lysosomes. Therefore, live Salmonella survive in a specialized compartment. Here we show that scavenger-receptor-mediated intracellular delivery of muramyl dipeptide (MDP) to macrophages leads to efficient killing of Salmonella ...

The aim of the present study was to examine the influence of technetium methylenediphosphonate (99Tc-MDP) on the proliferation and differentiation of human osteoblasts. Human iliac cancellous bone was isolated and cultured with either 99Tc‑MDP, β fibroblast growth factor (as a positive control) or medium only (as a negative control). Proliferation was assessed by direct cell counting, CCK‑8 ass...

To evaluate the influence of convergence angle tooth preparations and abutments height several surface treatments for zirconia copings through tensile retention test. 120 crown were made in Nema G10 with maxillary first molar anatomy. In total, 60 5 mm divided into two groups 6° 20° angles preparations, a 12° 4 6 heights. Three used MDP-primer (10-Methacryloyloxydecyl dihydrogen phosphate), gla...

This study evaluated the effect of chairside and laboratory types of surface conditioning methods on the adhesion of dual-cure resin cement with MDP functional monomer to zirconia ceramic after thermocycling. Disk-shaped (diameter: 10 mm, thickness: 2 mm) Y-TZP ceramics (Lava, 3M ESPE) were used (N=40) and finished with wet 1200-grit silicon carbide abrasive paper. Specimens were randomly divid...

Statement of the Problem The clinical success of ceramic depends on the quality of the bond between the zirconia and resin cement. Purpose In the present study, the effects of universal and conventional MDP-containing primers were evaluated on the shear bond strength of zirconia ceramic and nanofilled composite resin. Materials and Method Thirty blocks of zirconia ceramic (6mm×2mm) were pre...

Objetivos: Analizar la resistencia de unión al cizallamiento inmediata y a largo plazo restauraciones zirconia sistemas adhesivos disponibles en nuestro mercado que contienen molécula 10-MDP su composición.Métodos: Se crearon 20 especímenes zirconia, fueron arenados con partículas alumina divididos aleatoriamente 4 grupos según el agente acondicionamiento químico: Single Bond Universal (3M ESPE...

This study aimed to examine the shear bond strength between cobalt chromium alloy and autopolymerizing acrylic resin using experimental primers containing 5, 10, and 15 wt% of 4-methacryloxyethyl trimellitic anhydride or 1, 2, and 3 wt% of 3-methacryloxypropyl-trimethoxysilane comparison to 5 commercial primers (ML primers, Alloy primer, Metal/Zirconia primer, Monobond S, and Monobond plus). Si...

The synthesis and biological activity of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with tuftsin and retro-tuftsin derivatives containing isopeptide bond between ε-amino group of lysine and carboxyl group of simple amino acids such as Ala, Gly and Val are presented. We presumed, based on the cytokine profile, that the examined conjugates of tuftsin and MDP wer...