BACKGROUND We have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein A-IMilano (apoA-Im)/phospholipid complex. In this study, we sought to determine the effects of local recombinant apoA-Im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (ETC-216) delivered intramurally via the Infiltrator catheter on luminal narrowing in ...

This study aimed to identify the assemblages (or subassemblages) of Giardia duodenalis by using normal or nested PCR based on 4 genetic loci: glutamate dehydrogenase (gdh), triose phosphate isomerase (tpi), β-giardin (bg), and small subunit ribosomal DNA (18S rRNA) genes. For this work, a total of 216 dogs' fecal samples were collected in Guangdong, China. The phylogenetic trees were constructe...

A Magnetoencephalography Study of 1 Visual Processing of Pain Anticipation 2 3 4 Andre G Machado , Raghavan Gopalakrishnan , Ela Plow , Richard C. Burgess 3, John 5 C Mosher 3 6 7 8 1 Center for Neurological Restoration, Neurological Institute, Cleveland Clinic 9 Cleveland, OH 10 2 Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 11 Cleveland, OH 12 3 Epilepsy ...

Cytochrome P450 2D6 (CYP2D6) metabolizes a wide range of therapeutic drugs. CYP2D6 substrates typically contain a basic nitrogen atom, and the active-site residue Asp-301 has been implicated in substrate recognition through electrostatic interactions. Our recent computational models point to a predominantly structural role for Asp-301 in loop positioning (Kirton, S. B., Kemp, C. A., Tomkinson, ...

Background. The management of choledocholithiasis has evolved from open common bile duct exploration (OCBDE) to therapeutic endoscopic retrograde cholangiopancreatography (ERCP) to laparoscopic common bile duct exploration (LCBDE). Each entails a degree of difficulty. Aim. To review 5-year results of bile duct exploration in an UGI unit. Methods. Common bile duct explorations (CBDEs) performed ...

We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201–216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44–59, induced cross-reactive T cells for IRBP 201–216 capable of producing T helper (Th)1 and Th17 cytokines, but fai...

3 Running Title: Boronic Acid Inhibitors and SHV 4 5 Jodi M. Thomson, Fabio Prati, Christopher R. Bethel, and Robert A. Bonomo* 6 7 8 Department of Pharmacology, Case Western Reserve University School of Medicine, 9 Cleveland, Ohio; Department of Chemistry, University of Modena, Modena, Italy; 10 Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 11 12 13 14...

In 1998, in the winter issue of Mathematics and Computer Education ([1]) Monte Zerger posed the following problem. He had noticed or discovered the Pythagorean triple (216, 630, 666); (216) + (630) = (666). Note that 216 = 6 and 666 is the hypotenuse length of this Pythagorean triangle. The question was, then whether there existed a digit d (in the decimal system) and a positive integer k (othe...

Megacins A-216 and A-19213 in Bacillus megaterium are plasmid encoded, as shown by analysis of cured, non-megacinogenic (Meg-) derivatives of strains 216 and ATCC 19213 and by polyethylene glycol-mediated protoplast transformation of Meg- bacteria with plasmid DNA. The results of both techniques implicated a 31-megadalton plasmid, pBM309, in megacin A-216 production and a 29-megadalton plasmid,...

Human aquaporin 4 has been studied using molecular dynamics (MD) simulations in the absence and presence of pulses of external static electric fields. The pulses were 10 ns in duration and 0.012-0.065 V/Å in intensity acting along both directions perpendicular to the pores. Water permeability and the dipolar response of all residues of interest (including the selectivity filter) within the pore...