OBJECTIVE To assess the effect of 9 mm tibial tuberosity advancement (TTA) on cranial tibial translation (CTT) in a cranial cruciate ligament (CCL)-deficient canine stifle model. STUDY DESIGN In vitro cadaveric study. ANIMALS Canine pelvic limbs (n=12). METHODS Each stifle was placed in a jig at 135 degrees with a simulated quadriceps force and tibial axial force. CTT distance was measure...

This study was aimed at identifying changes in equilibrium and movement control strategies in trans-tibial amputees (TTA) related to both the biomechanical changes and the loss of afferent inflow. The coordinations between equilibrium and movement were studied in traumatical TTA and in controls during transition from bipedal to monopodal stance. TTA failed to perform the task in a high percenta...

Introduction This initial cost-effectiveness evaluation compared the provision of transtibial bone-anchored prostheses (TTA-BAPs) with socket-suspended (TTA-SSPs) over a 6-year time horizon from governmental prosthetic care perspective. The purposes were to present ways we dealt barriers encountered during analysis. objectives detail extraction baseline and incremental costs utilities required ...

Tetracycline-dependent transgenes promise to be an important tool for investigating the time dependence of gene function during mouse development. The pivotal element of this approach is the recombinant tetracycline-dependent transactivator tTA. Using a modified gene trap approach we successfully generated mouse lines expressing tTA in a wide spread manner during embryogenesis. The transgenic m...

BENCHMARKS Conditional gene expression using the Tet system is well established in eukaryotes (1). The tetracycline-controlled transactivator (tTA) binds to P tet-1 in the absence of an effector and stimulates transcription of the successive target gene (2). Effector tet-racyclines abolish activation by tTA (Tet-Off). The reverse transactivator rtTA2 S-M2 contains a mutated tetR al-lele and act...

BACKGROUND Psychiatric patients often require chronic treatment with antipsychotic drugs, and while rats are frequently used to study antipsychotic-induced metabolic adverse effects, long-term exposure has only partially mimicked the appetite-stimulating and weight-inducing effects found in the clinical setting. Antipsychotic-induced effects on serum lipids are also inconsistent in rats, but in...

The Time-Triggered Architecture (TTA) provides a computing infrastructure for the design and implementation of dependable distributed embedded systems. A large real-time application is decomposed into nearly autonomous clusters and nodes and a fault-tolerant global time base of known precision is generated at every node. In the TTA this global time is used to precisely specify the interfaces am...

Low-power design became crucial with the widespread use of the embedded systems, where a small battery has to last for a long period. The embedded processors need to efficient in order to achieve real-time requirements with low power consumption for specific algorithms. Transport Triggered Architecture (TTA) offers a cost-effective trade-off between the size and performance of ASICs and the pro...

MOTIVATION TTA Lynx is a web-based service for finding, assessing and comparing coding sequences that contain TTA codons. This codon is most notable for being a regulatory switch that governs different aspects of the physiology of several GC-rich, Gram-positive bacteria belonging to genus Streptomyces, prolific producers of clinically important natural products. The ever-increasing pace of geno...

This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examine...