Background: Osteoarthritis (OA) is a progressive, age-associated disease that is characterized with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane. Considering the complications of common treatments of OA, including non-steroidal anti-inflammatory drug (NSAIDs) and corticosteroids, investigating new treatments for this disorder is crucial. Recently,...

Proof. Let pa ≡ sup{p ∈ [0, 1] : a(p) > 0}, pc ≡ sup{p ∈ [0, 1] : d(p,H) = 1}, τa ≡ inf{t > 0 : pt = pa, p0 = 1}, and τc ≡ inf{t > 0 : pt = pc, p0 = 1}. First, we show that in any equilibrium pa ≤ pc. Looking for a contradiction, suppose that pa > pc. Let’s consider the behavior of beliefs at the threshold pa. If a(pa) ≥ pa then λ(a(pa) − pa) ≥ 0 so beliefs never cross the threshold pa. On the ...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

Background This study aimed to investigate diverse structure of pulmonary blood vessels in patients with combined pulmonary atresia and ventricular septal defect and examine the effect on surgery result. Materials and Methods This cohort retrospective study was conducted on admitta...

Pediocin PA-1 is a food grade antimicrobial peptide that has been used as a food preservative. Upon storage at 4 degrees C or room temperature, pediocin PA-1 looses activity, and there is a concomitant 16-Da increase in the molecular mass. It is shown that the loss of activity follows first-order kinetics and that the instability can be prevented by replacing the single methionine residue (Met3...

Background: Pectin is composed of complex polysaccharides that can inhibit cancer metastasis and proliferation with no evidence of toxicity. In the present study, the apoptotic and necrotic effects of pectic acid (PA) on the rat pituitary GH3/B6 tumor cells has been investigated. Methods: GH3/B6 cells were cultured in the Ham’s F12 medium enriched with 15% horse serum and 2.5% fetal bovine seru...

AIMS To identify the relative contribution of plasminogen activators, particularly tissue plasminogen activator (t-PA) and specific plasminogen activator inhibitors (PAI-1, PAI-2), to the fibrinolytic changes associated with various types of liver disease or severe chemical and physical damage to the liver. METHODS Platelet rich (PRP) and platelet poor plasma (PFP) from patients with alcoholi...