The necessity of catastrophe modeling is stipulated both by the essential increase of losses due to recent natural and man-caused hazards and by the lack of reliable real observation data. Earthquakes are considered as an example of unpredictable catastrophic events of a great destructive force. A brief overview of different approaches to mathematical modeling of lithosphere dynamics is present...

Abstract Study question Dose Testis expressed 44 (TEX44) gene associated with spermatogenesis and TEX44 mutations required for male infertility ? Summary answer is in testis participated spermatogenesis. And of may be involved risk asthenozoospermia lead to subfertile. What known already The World Health Organization estimates that 7-9 % population worldwide struggle infertility. Asthenoteratoz...

Background: Respiratory infection can be an immediate precursor to stroke and myocardial infarction (MI). Influenza vaccination is associated with reduced risk of MI. This relationship has also been suggested for although it unclear if the effect consistent across age groups. Methods: Using administrative data in Alberta from September 2009 – December 2018 we modelled hazard any individuals rec...

BACKGROUND Nivolumab has shown significant survival benefit and a favorable safety profile compared with dacarbazine chemotherapy among treatment-naïve patients with metastatic melanoma in the CheckMate 066 phase III study. Results from the health-related quality of life (HRQoL) analyses from CheckMate 066 are presented. PATIENTS AND METHODS HRQoL was evaluated at baseline and every 6 weeks w...