Nephropathic cystinosis was first described in the early 1900s in a 21-mo-old boy who died of progressive anorexia; two siblings had previously died in infancy under similar circumstances (1). By meticulous observations and analyses, it became clear that abnormal cystine accumulation was characteristic of this autosomal recessive disease (2-4). Although some considered it to be a severe form of...

For a strictly totally positive M × N matrix A we show that the ratio IlAxllp/llxllp has exactly R = min{ M, N ) nonzero critical values for each fixed p ~ (1, ~ ) . Letting ~ denote the i th critical value, and x ~ an associated critical vector, we show that ~l > " " " > An > 0 and x i (unique up to multiplication by a constant) has exactly i 1 sign changes. These critical values are generaliz...

The ThyA gene that encodes for thymidylate synthase (TS) is absent in the genomes of a large number of bacteria, including several human pathogens. Many of these bacteria also lack the genes for dihydrofolate reductase (DHFR) and thymidine kinase and are totally dependent on an alternative enzyme for thymidylate synthesis. Thy1 encodes flavin-dependent TS (FDTS, previously denoted as TSCP) and ...

Upper and lower bounds are proved for We find it useful to group a process' !;tates the shared space requirements for solution of sevinto four regions: the ~ or!!'..Yl!!9. ~~ coneral problems involving resource allocation among sists of those states which a process can be in asynchronous processes, Controlling the degradawhile running its entry protocol, and the exit ti on of performance when a...

This study explored the efficacy of conjoint behavioral consultation (CBC) by assessing objective outcomes and social validity with a sample of students with and without di versity. Diversity characteristics that were investigated included ethnicity, socioeco nomic status, family composition, maternal education level, and language spoken in the home. Behavioral change, goal attainment, acceptab...

Abbas, H.K., Zablotowicz, R.M., Shier,W. T., Johnson, B. J., Phillips, N.A.,Weaver,M. A., Abel, C. A., and Bruns, H.A. 2015. Aflatoxin and fumonisin in corn (Zea mays) infected by common smut Ustilago maydis. Plant Dis. 99:1236-1240. Corn infected with Ustilago maydis (common smut) produces galls that are valued as a delicacy in some cultures. During a 4-year period, aflatoxin levels in asympto...

•Unified solution to decarboxylative cross-nucleophile coupling reactions•Photoactive Fe(III) carboxylates + Fe(III)-mediated oxidation•Fe(III) salts are non-toxic, earth abundant, and low cost•Direct formation of C–C, C–O, C–S, C–N bonds without prefunctionalization Carboxylic acids valuable chemical building blocks because they widely available with significant structural diversity. Decarboxy...

I first summarize Baltag and Smets’ contribution to this volume, and praise their work. Then I compare the anti-lexicographic plausibility update that they propose to a proposal by Aucher, as an illustration of the difference between a qualitative and a quantitive formulation of updates. I quote Spohn’s original work that is at the root of research in plausibility updates and of the notion of a...

The phosphoinositide 3-kinase (PI3K)/Akt pathway is commonly activated in cancer; therefore, we investigated its role in hypoxia-inducible factor-1A (HIF-1A) regulation. Inhibition of PI3K in U87MG glioblastoma cells, which have activated PI3K/Akt activity secondary to phosphatase and tensin homologue deleted on chromosome 10 (PTEN) mutation, with LY294002 blunted the induction of HIF-1A protei...