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BACKGROUND This analysis was carried out to evaluate the long-term survival of patients with metastatic melanoma who received ipilimumab, a fully human monoclonal antibody that binds to cytotoxic T-lymphocyte antigen-4, in clinical trials. PATIENTS AND METHODS Patients received ipilimumab in one of three completed phase II clinical trials (CA184-008, CA184-022, and CA184-007). Previously trea...
Methods CRP and SAA were systematically measured during the follow-up of consecutive attack-free FMF outpatients seen in a pediatric and an adult French reference center. Dissociations between CRP and SAA were defined by normal CRP (<5mg/L) and elevated SAA (group A), or elevated CRP and normal SAA (<10mg/L) (group B). Demographic data, genotype, clinical characteristics of FMF, and treatment w...
OBJECTIVE To explore personality and readiness to change among substance use disorders (SUD) patients with and without ADHD. METHOD SUD + ADHD versus SUD - ADHD patients consecutively entering treatment between 2010 and 2012 were compared concerning personality (Temperament and Character Inventory) and readiness to change (Stages of Change Readiness and Treatment Eagerness Scale). RESULTS A...
The Tip-Edge bracket features the first and only archwire slot that offers variable control levels. It’s .022" archwire slot can increase in size to .028" relative to the archwire during retraction yet close back down to .022" to facilitate final finishing. Variable control eliminates the excessive anchorage strain and bite deepening that occurs during retraction with conventional edgewise appl...
پسماند چوبی درشت ) coarse woody debris ( یکی از اجزای مهم اکوسیستم جنگل است که نقش مهمی در فرآیندهای این اکوسیستم ایفا میکند. طی دهه اخیر توجه فراوانی به این جزء مهم بومسازگان توسط بوم- شناسان و جنگلشناسان شده است و روشهایی برای نمونهبرداری این جزء مهم اکوسیستم معرفی شده که همگی قطعات cwd را با احتمال نابرابر به عنوان نمونه انتخاب می نمایند. pds ( perpendicular distance sampling ،) dls ( dis...
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