We introduce and explore an approach to estimating statistical significance of classification accuracy, which is particularly useful in scientific applications of machine learning where high dimensionality of the data and the small number of training examples render most standard convergence bounds too loose to yield a meaningful guarantee of the generalization ability of the classifier. Instea...

Radon gas in the home is a major source of public radiation exposure and an established cause of lung cancer. A range of techniques are available to reduce high indoor radon concentrations in homes. Information on some 2,700 radon remediation projects has been analysed with the aim of identifying the factors that influence the performance of various remediation methods, including the specific r...

Introduction Familial Mediterranean fever (FMF) is an autosomal recessive disease that is prevalent among eastern Mediterranean populations, mainly non-Ashkenazi Jews, Armenians, Turks, and Arabs. Arthritis seen in FMF patients is generally acute monoarthritis which predominantly affecting the lower limbs, and it occurs during attack periods and also is a common clinical manifestation in patien...

Introduction Systemic reactive (AA) amyloidosis represents the most important complication within TNF receptor associated periodic syndrome (TRAPS), familial Mediterranean fever (FMF) and other autoinflammatory syndromes, progressively leading to endstage renal failure. The homozygous condition of the serum amyloid A (SAA) variant SAA1.1 is significantly associated with the occurrence of AA amy...

Methods To understand the complexity of intracellular signalling pathway perturbation in TRAPS, a prototypic mutant TNFR1 (C33Y), or wild-type TNFR1 (WT), were expressed at near physiological levels in an SK-Hep-1 cell model system. TNFR1-associated signalling pathway intermediates were examined under a range of conditions, employing reverse-phase protein microarray. Peripheral blood mononuclea...

B. B. Basak, Sharmistha Pal and S. C. Datta* Division of Soil Science and Agricultural Chemistry, Indian Agricultural Research Institute, New Delhi 110 012, India Present address: Directorate of Medicinal and Aromatic Plant Research, Boriavi, Anand 387 310, India Present address: Central Soil and Water Conservation Research and Training Institute, Research Centre, Madhya Marg, Chandigarh 160 01...

Oxidation by permanganate: synthetic and mechanistic aspects Sukalyan Dash , Sabita Patel , Bijay K. Mishra a,* Centre of Studies in Surface Science and Technology, Department of Chemistry, Sambalpur University, Jyoti Vihar, Burla 768 019, India Department of Chemistry, University College of Engineering, Burla 768 018, India Department of Chemistry, National Institute of Technology, Rourkela 76...